Endocrine Abstracts

Pathogenic variants in the SDHx genes are responsible for ~20% of familial Phaeochromocytoma/Paraganglioma (PPGL) tumours. Metastatic disease is lower in SDHD in comparison to SDHA, B and C mutations. Although the genotype-phenotype relationship is not well established it is considered that truncating SDHD pathogenic variants have a higher risk of causing disease in comparison to missense variants. We present two cases of metastatic paraganglioma in patients with heterozygous ...

Background and Aim: Approximately 1500 people attend the Beacon Health Check Department annually involving a panel of blood tests being screened. Our aim was to compare what percentage of this asymptomatic population have diabetes or were pre-diabetic and what percentage of these were undiagnosed and therefore untreated conditions.Methodology: This audit was a retrospective review of data collected from patients attending the Beacon Hospital Health Check...

RCTs and real-life studies have shown the efficacy of GLP-1 RAs on weight loss, glycemic outcomes, and prevention of cardiovascular (CV) events, but long-term data are lacking. This was a retrospective cohort study of 253 patients with a first prescription of a GLP-1 RA between 2009 and 2016 and a minimum follow-up of 5 years. The endpoints of the study were weight and glycemic outcomes. Secondary endpoints were the occurrence of renal and CV events, comparing patients with GL...

Background: Variable rate intravenous insulin infusion (VRIII) or ‘sliding scale’ is required for certain patients with diabetes to keep their blood glucose within the recommended target range during an acute illness or a period of starvation. When used in the right context this has shown to improve outcomes but can also lead to morbidity especially hypoglycaemia.Aim: Evaluate risk of hypoglycaemia in patients on VRIII with concurrent use of ba...

Introduction: Malignant pheochromocytomas present a real challenge for practitioners. This entity of tumors is rare, with complex characterization, and heterogenocity in their evolution and prognosis. Given the rarity of this tumor group, there is no consensus on the therapeutic management. The management must be in a multidisciplinary framework. Through this illustrative case, we propose a literature review of this rare entity with discussion of the different therapeutic opti...

The role played by physical activity in promoting bone health is now widely recognized. Physical activity limits and slows down the physiological demineralization that occurs over the years and plays an important role in the prevention of osteoporosis. SuperJump, a high-impact training activity performed on a mini-trampoline characterized by alternating between aerobic and anaerobic exercises, has been shown to be able to generate a substantial osteogenic response and increase...

Introduction: Ramadan is considered a sacred period during which Muslims practice fasting from sunset until dawn changing the rhythm of life and eating habits. The objective of this study is to evaluate diabetics diet during and after the holy month. Patients and methodsDescriptive cross-sectional study, including diabetic patients, seen during the month of Ramadan, conducted at the Department of Diabetology and Endocrinology of the CHU Ibn Rochd of Casablanca. Data collection...

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

Introduction: Sarcoidosis is a systemic inflammatory disease characterized by noncaseating granulomas. Its pseudo-tumor manifestation in certain organs such as the thyroid can mimic thyroid carcinoma and lead to erroneous therapeutic decisions. We report a case of sarcoidosis with cervical adenopathy initially considered as a cervical metastasis of thyroid cancer.Observation: A 61-year-old woman, with a history of spontaneous subacute subdural hematoma o...

Introduction: Basedowian exophthalmos is an inflammatory disease of the orbit of autoimmune origin, potentially threatening with severe functional and psychosocial effects. It is usually accompanied by hyperthyroidism. It constitutes a real diagnostic challenge in patients with euthyroidism, as is the case with our patient.Observation: A 34-year-old young woman with no particular pathological personal or family history. Who initially consults, a year ago...