Endocrine Abstracts

Introduction: Pancreatic neuroendocrine neoplasms (PNEN) present with a fibrotic stroma which constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts over the growth of PNEN and their sensitivity to the mTOR inhibitor, RAD001, are as yet unestablished.Methods: We investigated reciprocal interactions between 1) human PNEN cell lines (BON-1/QGP-1) or primary cultures of human ileal neuroendocrine neoplasm (iNEN) or PNEN, and 2)...

Introduction: The variable tumor behavior in patients with gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) is challenging. Current general biomarkers are insufficient to predict the disease course. An emerging biomarker is the NETest, a blood-based gene signature that can predict disease status based on the expression of genes involved in tumor biology. While promising, the accuracy and reproducibility of results in daily practice during years of follow up has never b...

Medical treatment of acromegaly is based on either suppressing pituitary GH secretion or inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of IGF1. AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) derived from peptide sequences discovered using a unique, cell-free in vitro transcription-translation system screened against the human GHR, and that was optimized by rational design to increase...

Background: Hyperthyroidism caused by autonomous functioning thyroid nodules (ATN) is usually treated with I-131. Recently, radiofrequency ablation (RFA) has emerged as a promising alternative but it is not yet incorporated in guidelines.Aims: Assessment of efficacy of RFA treatment in patients with hyperthyroidism caused by ATN and factors that may affect treatment success.Methods: Retrospective analysis of patients treated for hy...

We report an interference in an immunoassay for aldosterone, which potentially could have led to a wrongful diagnosis and unnecessary surgery. The interference was serendipitously recognized due to a preanalytical error. A 59-year-old female patient with hypertension was referred to the department of endocrinology after an adrenal incidentaloma was detected. Because of her hypertensive history, screening for primary hyperaldosteronism was performed. An elevated aldosterone and...

Objective: Anaplastic thyroid carcinoma (ATC) and primary thyroid lymphoma (PTL) are two highly aggressive malignancies of the thyroid, both leading to a rapidly enlarging neck mass. Fine-needle aspiration cytology (FNAC) is generally performed as the primary examination for diagnosis in thyroid pathology but shows low sensitivity in diagnosing ATC or PTL. Non-diagnostic FNACs are usually followed by core-needle biopsy (CNB) or diagnostic surgery. As sensitivities of up to 100...

Background: A quarter of UK children now leave primary school obese. Childhood obesity is associated with significant comorbidity including obstructive sleep apnoea, type 2 diabetes, non-alcoholic fatty liver disease, hypertension and depression. We report our experience of using semaglutide, a weekly subcutaneous GLP1 receptor agonist, as a weight-loss adjunct for severely obese children in combination with dietary and lifestyle support from a multidisciplinary team.<p cl...

Introduction: Patients with adrenal insufficiency (AI) are known to have a higher cardiovascular risk (CVR) than the normal population. In particular arteriosclerosis, coronary heart disease, arterial hypertension, hyperlipoproteinemia as well as metabolic disturbances contribute to the increased morbidity and mortality. Aim of this study was to evaluate known cardiovascular risk factors as well as the quality of care by the treating physicians.Material ...

Section 1: Case history : The case concerns a 53-year-old gentleman who developed calciphylaxis following a bioprosthetic aortic valve replacement. His past medical history included Multiple Endocrine Neoplasia Type 1 (MEN-1) for which he had previously undergone total parathyroidectomy with failed graft auto-transplantation. The resulting hypoparathyroidism was managed with alfacalcidol and calcium supplements. Post cardiac valve replacement he developed acute renal injury an...

Background: Neonatal cortisol assessment is indicated in suspected adrenal insufficiency.Aims/objectives: Review of neonatal cortisol assessment within our Trust over seven years, to analyse trends, indications, outcomes; and relationships between gestational age (GA), birth weight (BW) and cortisol assessment.Methodology: From cortisol results on neonates (≤30 days age) between 2012–2018 (inclusive) we identified random...