Endocrine Abstracts

Background: Cabergoline (CAB) is the most effective dopamine agonist (DA) used for the treatment of macroprolactinoma. Few data on the dose of CAB necessary for achieving and maintaining normal prolactin (PRL) levels are available. We aimed to study these parameters in a large series of patients with macroprolactinomasMethods: We retrospectively analysed the clinical, biochemical and imaging features at diagnosis and the treatment response to CAB (dose n...

Glucocorticoid, known as cortisol, is a steroid hormone essential to the maintenance of homeostasis, and is released in response to stress and low blood glucose concentration. It is converted from cortisone by 11β hydroxysteroid dehydrogenase type 1 (11β HSD1). The liver plays a major organ in metabolism, has numerous functions, mostly consists of hepatocytes, and is a principal target of cortisol. In murine model, it was observed that too much cortisol or overexpres...

Both metabolism and cardiac function fluctuate over the course of the day according to energy supply and demand. The triiodothyronine (T3) regulates several genes related to metabolism and function in cardiomyocytes. Our previous data have suggested that there is a potential interrelationship between the regulation of cardiac function by T3 and the intrinsic circadian clock in the heart. Considering that: i) the hypothyroidism is associated to a reduction...

Background: We investigated the frequency of autoimmune thyroid and diabetes antibodies in patients with type 1 diabetes mellitus (T1DM), their siblings, and controls.Methods: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulin autoantibodies (IAA), and thyroid antibodies were identified in all subjects.Results: The rates of positive GADA and IAA were significantly higher in probands compared to sibl...

Thyroid cancer is one of the common head and neck malignancies and may be found incidentally with other head and neck cancers. The purpose is to evaluate the prevalence and risk of malignancy in incidental thyroid lesions identified by ultrasound (US) in patients with head and neck cancer. We retrospectively reviewed medical records of all patients with head and neck cancer other than of thyroid origin between January 2004 and January 2012. A total of 697 patients (542 men and...

Background: Many young people have inadequate follow up because they lose contact with adult care following transfer from paediatrics. There is a need to adapt communication interventions to help young people to determine and enact their preferred involvement in consultations with health professionals.Objective: To develop interventions to support communication with young people in endocrine care and to assess the feasibility of implementation in routine...

Background: Urinary metanephrine (MN) and normetanephrine (NMN) are used to detect recurrence of pheochromocytoma during post-operative period. Currently, reference ranges of urinary MN and NMN obtained from healthy individuals are applied to subjects with adrenalectomy. However, studies regarding the property of using reference ranges from healthy subjects in pheochromocytoma subjects with adrenalectomy are limited.Aim: To compare urinary MN and NMN con...

Glucagon-like peptide-1 (GLP-1) is known to stimulate insulin and somatostatin secretion in pancreatic islet cells. The exogenous somatostatin inhibits insulin secretion, but GLP-1 increases insulin secretion in spite of stimulating somatostatin secretion from δ-cell. So, we investigated whether there exists a time difference of insulin and somatostatin secretion inside the islets after GLP-1 stimulation or insulin secretion depends on secreted GLP-1 or somatostatin conce...

Objective: This study was performed to determine the impact on quality of life and sleep impairment of painful diabetic peripheral neuropathy (PDPN).Research design and method: The study pool consisted of 200 randomly selected peoples with type 2 diabetic peripheral neuropathy. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study S...

Background/aims: Maternal subclinical hypothyroidism has been reported to be associated with risks of adverse pregnancy outcomes such as fetal loss and possible fetal neurodevelopmental deficit. However, current guidelines seem to overestimate subclinical hypothyroidism in pregnant women in some regions. Therefore, we aim to evaluate trimester-specific reference range of serum TSH for pregnant women in Korea and whether maternal subclinical hypothyroidism affects perinatal out...