Endocrine Abstracts

The estrogen receptor is encoded by two genes (ER-alpha and ER-beta). Both function as transcription factors to modulate expression of target genes. ER-alpha has been shown to interact with co-regulators to enhance or inhibit transcription in vitro. We hypothesised that the existence of these co-regulators contribute to the differing clinical response of patients to treatment with the anti-estrogen four hydroxytamoxifen (4-HOT). The aim of this project was to localise ER-alpha...

The proto-oncogene Gsalpha has been implicated in a significant minority of somatotrophinomas, but the search for candidate oncogenes in the remaining somatotrophinomas, and in the great majority of other types of benign pituitary adenomas, has so far been unsuccessful. Microarray-based comparative genomic hybridisation (microarray-CGH) is a novel DNA microarray technique that has been shown to identify gain or loss at the gene level, and has been proposed as a tool to screen ...

Background: Metformin plays anti-tumoral roles in human cancers including breast and thyroid. However, its effects on metastatic lesions are undetermined. We studied the effects of metformin on bone metastasis of thyroid cancer.Method: Luciferase-tagged anaplastic FRO and follicular FTC 133 thyroid cancer cells were used. In vivo effects of metformin were evaluated in both ectopic tumor model and bone metastasis model generated by intratibial injection.<...

Background: This study examined the associations between diabetes (DM) and falls in Korean using data from a large population-based survey.Methods: This study analyzed 126 200 men and women (aged ≥50 years) who participated in Korean Community Health Survey in 2013. Logistic regression was used to assess the relationship between DM and falls.Results: The mean (±S.D.) of age, and body mass index was 64.9&#1...

Background and aims: Atherosclerosis is more prevalent among people with chronic kidney disease (CKD) than among those with normal renal function. Ankle-brachial index (ABI) and toe-brachial index (TBI) are a simple useful method for assessing peripheral atherosclerosis. The aim of our study was to investigate whether ABI or TBI were more strongly associated with progression of diabetic nephropathy such as change of urinary albumin/creatinine ratio (ACR), serum creatinine leve...

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

Objective: Despite beneficial effect of FGF-21 on metabolic disease, there were concerns about adverse effect on bone metabolism, supported by animal studies. However, a recent human study showed the positive association between FGF-21 and bone mineral density (BMD) in health premenopausal women. This study was undertaken to examine the association between FGF-21 and BMD in healthy postmenopausal Korean women who are susceptible to osteoporosis.<p class="a...

Objective: Dipeptidyl peptidase (DPP)-4 is highly abundant in the kidney. In various chronic inflammatory diseases, soluble DPP-4 activity is used as a marker for diabetes, coronary artery disease and cancer. This study examined the association between serum soluble DPP-4 levels and renal function or cardiovascular risk in patients with type 2 diabetes mellitus.Research design and methods: Soluble DPP-4 activities were measured retrospectively in a total...

Objective: Dapagliflozin, sodium-glucose cotransporter-2 (SGLT-2) inhibitor, reduces hyperglycemia and body weight by inhibiting renal glucose reabsorption. However, only a few studies have shown the glycemic efficacy on a combination of dapagliflozin in type 2 diabetic patients in Korean. We evaluated the efficacy and safety of glucose control on a combination of dapagliflozin in people with type 2 diabetes in Korea.Methods: This is a retrospective, obs...

Background/objectives: This study aimed to investigate associations between self-reported sleep duration and general and abdominal obesity in Korean adults stratified according to sex and age.Subjects/methods: Data from 41,805 adults, 18–110 years of age, collected by the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007 and 2015, were included. Obesity was defined as body mass index (BMI) ≥25 kg/m2, and abdo...