Endocrine Abstracts

Objective: Having a psychiatric disorder may increase the risk of developing type 2 diabetes (T2D) and we aimed to determine whether young adults with a psychiatric disorder have an increased risk of developing T2D.Research Design and Methods: We conducted a nationwide cohort study to evaluate the association of different psychiatric disorders with the risk of T2D in the young population. Records of 6.457.991 adults aged 20−39 years without a histo...

The primary cilium, a non-motile microtubule-based organelle protruding from most vertebrate cells, serves as a specialized compartment for signal transduction. Any disruption of ciliogenesis leads to ciliopathy-spectrum disorder with multiple signalling failure in development and homeostasis. Several ciliopathies including Bardet–Biedl syndrome associate with infertility and hormone imbalances, but the role of primary cilia in reproductive disorders is not clear. Congeni...

Background: The brain’s thermoregulatory center is stimulated by activation of neurokinin 3 receptor (NK3R) and inhibited by estrogen. In menopause, declining estrogen disturbs this balance, producing vasomotor symptoms (VMS). This study assessed response to the NK3R antagonist fezolinetant in women with menopausal VMS.Methods: This phase 2b, double-blind trial (NCT03192176) randomized menopausal women (age >40−65 y) with moderate/severe V...

Bone morphogenetic proteins (BMPs) exhibit broad spectrum of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-β (TGF-β) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. BMPs together with other intraovarian growth factors are intimately involved in re...

Context: CHH/KS is a major cause of pubertal and bone maturation delay due to sex steroids deficiency. FH and TH have not been evaluated in large series of CHH/KS patients. Analysis of auxometric measures in patients’ siblings has never been performed.Patients and methods: We selected 216 (164/52 men/women; 112/104 KS/normosmic CHH) with available auxometric measures. Sibling stature was available in a subgroup of 162 patients. Difference between th...

Objective: Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium – glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes(T2D) at high CV risk. SGLT2-i should be considered as a valuable therapy in T2D with established atherosclerotic cardiovascular disease (ASCVD) or heart failure (HF). We analyzed the effects of cardiovascular function of SGLT 2 inhibitors in T2D with ASCVD or HF compared with dipeptidyl peptidase-4...

Previously, we reported that aphidicolin acutely increases nitric oxide (NO) production in bovine aortic endothelial cells (BAECs) by increasing phosphorylation of endothelial nitric oxide synthase at serine 1179 (p-eNOS-Ser1179) and decreasing phosphorylation at serine 116 (p-eNOS-Ser116) without altering eNOS protein expression. Here, we demonstrate that prolonged treatment with aphidicolin (over 24 h) also increased NO production in BAECs. Unlike the a...

The cytosolic calcium concentration is regulated by calcium-processing proteins such as transient receptor potential cation channel subfamily V member 5 (TRPV5), TRPV6, sodium-calcium exchanger 1 (NCX1) and plasma membrane Ca2+ ATPase 1 (PMCA1). Those calcium-processing proteins are important for physiological functions in the brain. The effects of steroid hormones on calcium-processing protein expressions in the brains are undescribed. Thus, the effects of steroid ...

Calbindin-D9k (CaBP-9k), one of the major calcium-binding and calcium-buffering proteins, is important in the physiological functioning of organs. The neuroanatomical localization of CaBP-9k in the rodent brain has not been reported; thus, this study investigated the neuroanatomical distribution of CaBP-9k and the regulation of CaBP-9k expression on steroid hormones in the immature rat brain. To confirm the influence of steroid hormones on CaBP-9k expression, immatu...

Background: The National Health Insurance Service of South Korea is considered to be one of the most effective systems in the world with high accessibility to health care for all Koreans including foreign residents in the country as many as 50 M people. The accumulative information on the behaviors and the statistics of healthcare use based on the National Health Insurance Sharing Service Database has become important for medical research as a nationwide surveillance.<p cl...