Endocrine Abstracts

Introduction: Hypothyroidism is one of the major causes of preventable mental retardation. Neonatal screening aids in the prompt diagnosis of newborns with congenital hypothyroidism. There are other clinical conditions that can alter thyroid function during the newborn period, including exposure of high iodine concentrations.Case presentation: One day old female born at 37 3/7 weeks of gestational age by C-section with imperforated anus and congenital he...

Objectives: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of β-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of oestradiol (E2) is decreased. The aim of the present study was to determine the effect of neuropeptide, neurokinin B (NKB) and amyloid beta fragment Aβ (25–35) on E<sub...

Objective: The objective of this study was to investigate beneficial effects of metformin on membrane bound enzymes (monoamine oxidase, Na+K+ ATPse) and antioxidant enzymes (sueroxidase dismutase and glutathione S-transferases), lipid peroxidation, neurolipofuscin, and DNA degradation in diabetic aging female rats.Methods: Young (3 months) adult (12 months) and aged (24 months) rats will be diabetic by using alloxan monohyd...

Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. AD is characterized by the presence of amyloid plaques which are formed from deposits of b-amyloid protein (Ab). These changes increase during menopausal condition in females when the level of estradiol is decreased.Objective: The objective of this study was to investigate neuroprotective potential of 17β estradiol (E2) treatment on the activities of acetyl...

Introduction: Recombinant parathyroid hormone 1–34 (PTH(1–34)) and 1–84 (PTH(1–84)) stimulate new bone formation and are associated with significant decrease in the risk of vertebral and non-vertebral fractures. De novo autoimmune hepatitis (AIH) is a rare graft dysfunction occurring in patients having undergone liver transplantation (LT) for causes other than AIH.Case report: A 61-year old woman was referred to our metabolic b...

Background: Melatonin as strong antioxidant and free radical scavenger can play important, protective role in disease in which oxidative damage is a significant component e.g.: in coronary heart disease, neoplastic disease, neurodegenerative disease. The aim of our study was determination of the effect of melatonin supplementation on malonyldialdehyde (MDA) concentration and activity of: superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in patients...

5-Alpha reductase deficiency is a rare 46, XY disorder of sex differentation caused by mutations in the 5-alpha reductase type 2 gene (SRD5A2) located on chromosome 2p23. Affected patients have a deficiency of the 5-alpha reductase type 2 enzyme, which becomes partially or totally unable to convert testosterone into dihydrotestosterone, the latter being responsible for the development of the external genitalia, prostate, and urethra in the male fetus. Most affected individuals...

Summary: The autoimmune polyglandular syndromes (APS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (APS 1) and a relatively common adult type with (APS 2) or without adrenal failure (APS 3). APS 1 is caused by mutations in the autoimmune regulatory (AIRE) gene on chromosome 21 and is inherited in an autosomal recessive manner. Mutations of the AIRE gene result in defective proteins which cause autoimmune destruction of target organ...

It is to delineate two categories of hypercalcemia: hypercalcemia associated with dysfunction of the parathyroid gland and hypercalcemia that occurs despite appropriate parathyroid suppression.There is casuistic model of 73 years old woman with several years personal history of hypercalcemia and clinical polyarthritis. After standard examinations there was diagnosed primary hyperparathyroidism. USG screening expected adenoma of parathyroid gland right do...

Multiple endocrine neoplasia type 2A (MEN2A) is an inherited syndrome caused by the mutation of RET gene. The classic variant of this syndrome includes the presence of medullary thyroid carcinoma (MTC), in association with pheochromocytoma and parathyroid neoplasia. MTC is usually the first presentation, with palpable neck mass and hypercalcitonemia, metastatic spread to local lymph nodes or distant sites.We report the case of a 41 year old Caucasian man...