Endocrine Abstracts

Context: Clinical studies are needed to classify rare and novel RET mutations associated with hereditary medullary thyroid carcinoma (MTC) into one of three clinical risk groups.Objective: We analyzed genotype–phenotype correlations associated with the RET protooncogene mutation R770Q in exon 13 which was detected simultaneously with a Y791N mutation in the same family.Results: Calcitonin determination in a 43-year-old female ...

Background: Obesity is a rising problem in developed and developing countries. Currently little is known about prevalence and prognosis of type 2 diabetes and the metabolic syndrome in obese children and adolescents in Europe.Patients and methods: About 491 obese children (mean-age 11.2 years; mean-BMI 30.3 kg/m2) were examined (lipid-profile; blood pressure, insulin-resistance1) and in 102 of them with risk factors for type 2 diabe...

Objective: Insulin resistance (IR) has been reported in first-degree male relatives of patients with IC (FDMR). Retinol binding protein-4 (RBP4) has been shown to be increased in IR. We hypothesized that RBP4 would be: 1) increased in FDMR compared with controls and 2) correlated with features of IR.Methods: The study was approved by Leeds (West) Research Ethics Committee. We measured RBP4 in 162 healthy FDMR previously found to be more insulin resistant...

Synthetic peroxisome proliferator-activated receptor gamma (PPARγ) ligands are used clinically to improve insulin sensitivity. Although designed as specific ligands for PPARγ, there is evidence for some ‘off target’ effects being mediated by a non-classical, non-PPARγ mechanism. Recent evidence further suggests that some of these effects may be glucocorticoid receptor (GR)-dependent.To analyse activation of GR following exposure ...

Semen quality and reproductive hormones may be affected in men with testicular neoplasia (TN) and lymphoproliferative disorders (LD). We evaluated these parameters before, 6, 12 and 24 months after the end of the oncological treatments in 60 patients with TN, and in 35 patients with LD. The patients were divided on the bases of the basal sperm concentration (A< and B≥ 10 million/ml). FSH, LH, testosterone (T) and inhibin B levels and sperm parameters were evaluated i...

Background: It is well established that diabetes-related complications are greatest in patients with a high HbA1c and in those who do not attend primary or secondary care clinics. For an equivalent reduction in HbA1c greater benefits are achieved in those with a high baseline.Aim: To determine if a simple action plan implemented by the Diabetes and Practice Nurse in primary care could improve glycaemic control.Methods: A primary ca...

Introduction: The long-term mountain cycling effects on cognitive development for better performance, are still not fully elucidated. Notwithstanding, this type of exercise may induce a link with energy metabolism and sympathetic nervous system. We previously observed that a mountain cycling ultramarathon, induced a comodulatory influence of genetic- and exercise-associated factors on inflammatory and haemoglobin catabolic marker haptoglobin. We hypothesised that inflammatory ...

Introduction: The interaction between bone and energy metabolism may be enhanced in high demanding physical activities. We hypothesize that genetic background may modulate the exercise-associated bone and energy responses of athletes participating of a mountain cycling ultramarathon.Methods: Fifty-five non-professional athletes (mean age 44.8±7.1 years) participating in a 9-day mountain cycling ultramarathon (TransPortugal) were evaluated. Before an...

Pituitary stem cells have been characterized in the postnatal pituitary. We now know they are organized in a niche and co-express specific markers such as Sox2, Sox9 or Gfra2. Although many studies by our group and others have been dedicated to its characterization in situ it is under discussion their role in the maintenance and turnover of the pituitary in physiological conditions or physiological pituitary challenges. It’s not known if the stem cells are requir...

Changes in estimated glomerular filtration rate (eGFR) over 5 years were evaluated in adult patients with chronic hypoparathyroidism. A cohort of patients treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), was derived from NCT01297309 (RACE) and NCT01199614 (HEXT) clinical trials. A historical control patient cohort with hypoparathyroidism who did not receive rhPTH(1–84) or rhPTH(1&#...