Endocrine Abstracts

Androgens are considered beneficial for athletic performance by potent anabolic effects on muscle mass and bone tissue. Testosterone also increases circulating hemoglobin, which will enhance oxygen uptake. Furthermore, androgens may exert behavioral and psychological effects of importance for athletic performance including increased mental drive and competitiveness. Studies in men have shown clear relationships with both exogenous and endogenous circulating testosterone to mus...

Recent studies have suggested that subjects receiving thyroxine replacement therapy are in potentially increased risk of osteoporosis. We set out to measure bone mineral densities by ultrasound bone densitometry (UBMD) in three groups: group A of post-menopausal women (N=25) mean age 65 (±14), group B of women in generative period (N=20) mean age 41(±11), and group C (N=18) male mean age 54, receiving thyroxine replacement therapy during two year...

Type 2 diabetes manifests when pancreatic β-cells secrete inadequate insulin in response to elevated glucose. A known culprit in metabolic diseases is excessive exposure to glucocorticoids (GCs). GCs increase hepatic gluconeogenesis, decrease insulin sensitivity in skeletal muscle and adipose tissue and suppress the development of β-cells. In rodents, inactive GC 11-dehydrocorticosterone (A) is converted to active corticosterone (B) by the enzyme 11β-hydroxyster...

Authors agree that although mortality for COVID 19 is low, comorbidities may contribute to severe disease and mortality. Chinese center for disease control and prevention reported three times higher mortality in patients with diabetes. However, most studies do not take into account age of patients. Our study aimed to evaluate association of COVID in patients lesser than 65 years of age in two countries, India and United Kingdom with diabetes. We excluded patients with co-morbi...

The use insulin pump therapy (IPT) (continuous subcutaneous insulin infusion (CSII)) has increased dramatically in youth with type 1 diabetes (T1D) in the past decade.Objective: Rate metabolic compensation of diabetes mellitus in children on IPT on the level HbA1c and self-control of glycaemia.Methods: The examination of 19 children aged 12.55±3.75 years (boys/girls=13/6), with T1D, observed in ‘2nd City Children’s H...

Kisspeptin is a neuropeptide secreted in anteroventral-periventricular and arcuate hypothalamic nuclei involved pubertal onset and in other functions of adult life. Kisspeptin levels are sex dependent, so they are higher in prepubertal girls and in adult women compared to age-matched male. This sex-related pattern has been reported in adult obesity, but few data are reported in childhood obesity. In order to evaluate correlations between metabolic status and kisspeptin, we stu...

To achieve the optimal glycaemic control in adolescents with type 1 diabetes mellitus (DM1) is a difficult task. The reason is a low compliance of teenagers caused by psychoemotional peculiarities as well as decreased insulin sensitivity due to a physiologically high concentration of contrainsular hormones (androgens, GH, etc.). This study was aimed to determine peculiarities in regimens of the pump insulin therapy that are necessary for achieving treatment goals in adolescent...

Background: Hyponatremia in not uncommon in elderly. Common causes include medication, heart, kidney and liver diseases, digestive loses, syndrome of inappropriate anti-diuretic hormone. Hormonal imbalances are sometimes overlooked. Sudden onset after a recently invasive procedure could challenge the diagnostic.Methods: We present a case report of a severe hyponatremia diagnosed after a coronary angiogram. It is a rare case of hypopituitarism secondary t...

Introduction: Glucocorticoid replacement in adrenal insufficiency may be achieved by administering thrice- daily hydrocortisone or once-daily very low dose (2-4 mg) prednisolone. Prednisolone’s longer half-life enables once-daily dosing, improving patient satisfaction and compliance. At very low doses, it has shown no difference in most markers of metabolic risk when compared with hydrocortisone. At Imperial College Healthcare NHS Trust (ICHNT), use of an eight-hour troug...

Introduction: Liberal glucocorticoid replacement therapy prevents Addisonian crises in individuals with adrenal insufficiency (AI). Prednisolone is six to eight times more potent than hydrocortisone. There is inter-individual variation in glucocorticoid metabolism wherein 5 mg prednisolone once-daily may result in over-replacement in most individuals, with subsequent long-term morbidity and mortality.Methods: Data from individuals on established predniso...