Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0073aep839 | Late Breaking | ECE2021

Neuroendocrine neoplasm of the pancreas as a manifestation of familial isolated pituitary adenoma: A case report

Coopmans Eva , Korpershoek Esther , M.F. van Velthuysen , Adrian F. Daly , Beckers Albert , Aart Jan Van der Lely , Neggers Sebastian , Hofland Hans , Feelders Richard , Wouter W de Herder

ContextGermline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) have been identified in patients with pituitary adenomas, most frequently presenting as somatotropinomas in the setting of familial isolated pituitary adenoma (FIPA). Our current understanding of AIP related tumorigenesis indicates that it leads to isolated pituitary adenomans, while other associated tumors have not typically been considered part of the...
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ea0056gp217 | Reproduction | ECE2018

The first Belgian series of 56 patients with congenital hypogonadotropic hypogonadism (CHH): genetic and brain abnormalities

Valdes-Socin Hernan , Libioulle Cecile , Harvengt Julie , Pintiaux Axelle , Jonas Christelle , Parent Anne Simone , Geenen Vincent , Corman Vincianne , Debray Francois Guillaume , Dideberg Vincianne , T'Sjoen Guy , De Leerner Anne , Beckers Dominique , Destree Anne , Roland Dominique , Lederer Damien , Boscolo Marina , Bours Vincent , Maiter Dominique , Beckers Albert

Introduction: CHH is a genetic syndrome that combines reproductive and brain abnormalities. The brain phenotype has been incompletely characterized. We aimed to study neuroradiological and genetic features in this first Belgian series of patients with CHH.Methods: A series of 56 adult patients (48 males, 8 females) presenting with CHH was investigated for a panel of 16 genes related to hypogonadotropic hypogonadism by next generation sequencing on a MiSe...
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ea0037gp.03.01 | Adrenal (2) | ECE2015

Pregnancy in women with non-classical congenital adrenal hyperplasia: time to conceive and outcome

Eyal Ori , Segev-Becker Anat , Ayalon Irit , Schachter-Davidov Anita , Oren Asaf , Weintrob Naomi

Background: Non-classical 21-hydroxylase deficiency (NC21OHD) is a mild form of congenital adrenal hyperplasia associated with different degrees of postnatal virilisation. Elevated serum androgen concentrations have been reported to be a risk factor for infertility, early pregnancy loss, and recurrent miscarriages in women with polycystic ovarian syndrome (PCOS).Aims: The aim of this study was to assess time to conceive and pregnancy outcome in NC21OHD w...
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ea0028s8.3 | Small molecules, big effects: the emerging role of microRNAs | SFEBES2012

The regulatory role of miR-375 in the pancreatic β-cell secretome

Tattikota Sudhir , Rathjen Thomas , Sury Matthias , Becker Clinton , Selbach Matthias , Poy Matthew

MiR-375 regulates growth and function of the pancreatic beta cell, the source of a multitude of secreted factors into the systemic circulation which facilitate metabolic processes, most notably insulin. Here we provide mass spectrometric analysis addressing the impact of miR-375 on the pancreatic beta cell secretome. Quantitative proteomics detected over 600 proteins released in response to glucose using the murine beta cell line, MIN6. Furthermore, the secretome profiles foll...
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ea0050ja1 | Society for Endocrinology Journal Award - Journal of Endocrinology | SFEBES2017

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation

Iulia Potorac, Adolfo Rivero-Müller, Ashutosh Trehan, Michał Kiełbus, Krzysztof Jozwiak, Francois Pralong, Aicha Hafidi, Albert Thiry, Jean-Jacques Ménagé, Ilpo Huhtaniemi, Albert Beckers and Adrian F DalyJournal of Endocrinology, 2016 231 197–207. DOI: 10.1530/JOE-16-0384...
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ea0050ja1 | Society for Endocrinology Journal Award - Journal of Endocrinology | SFEBES2017

A vital region for human glycoprotein hormone trafficking revealed by an LHB mutation

Iulia Potorac, Adolfo Rivero-Müller, Ashutosh Trehan, Michał Kiełbus, Krzysztof Jozwiak, Francois Pralong, Aicha Hafidi, Albert Thiry, Jean-Jacques Ménagé, Ilpo Huhtaniemi, Albert Beckers and Adrian F DalyJournal of Endocrinology, 2016 231 197–207. DOI: 10.1530/JOE-16-0384...
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ea0041gh1biog | The Geoffrey Harris Prize Lecture | ECE2016

Geoffrey Harris Prize Winner

The European Society of Endocrinology is pleased to present the annual Geoffrey Harris Prize. This prestigious prize is designed for established researchers in the field of neuroendocrinology and is the first of its kind in Europe. The prize will be presented at the annual European Congress of Endocrinology, where the winner will be asked to give one of the main lectures, in addition to two other lectures at future ES...
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ea0032s21.2 | Multi-centre pituitary studies | ECE2013

Lessons from the Liège Acromegaly Survey (LAS)

Petrossians Patrick , Zacharieva Sabina , Chanson Philippe , Neggers Sebastian , Brue Thierry , Colao Annamaria , Hulting Anna-Lena , Delemer Brigitte , Hana Vaclav , Stalla Gunter , Minuto Francesco , Jaffrain-Rea Marie-Lise , Carvalho Davide , Montanana Carmen Fajardo , Beckers Albert

The Liège Acromegaly Survey is a cross-sectional study on acromegalic patients, developed as an in-house tool in Liège, then extended to other Europeans participating centers. The database differentiates itself from national and multinational registries by adopting a goal oriented approach and it was conceived following a list of open questions on acromegaly. After an initial test run in Liège, the database installation started on mid-March 2010. Thirteen other ...
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ea0022oc3.6 | Pituitary | ECE2010

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Tichomirowa Maria , Barlier Anne , Daly Adrian , Jaffrain-Rea Marie-Lise , Cozzi Renato , Yaneva Maria , Naves Luciana , Ronchi Christina , Sievers Caroline , Maiter Dominique , Montanana Carmen Fajardo , Zacharieva Sabine , Beckers Albert

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...
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ea0016p454 | Neuroendocrinology | ECE2008

Aryl hydrocarbon receptor interacting protein (AIP) expression in human pituitary adenomas

Jaffrain-Rea Marie-Lise , Spilioti Cristina , Vanbellinghen Jean-Francois , Daly Adrian , Gargano Donatella , D'Innocenzo Emanuela , Giangaspero Felice , Tichomirowa Maria , Esposito Vincenzo , Ventura Luca , Naves Luciana , Alesse Edoardo , Beckers Albert

Background: Germline AIP mutations confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated pituitary adenomas (FIPA); AIP mutations account for 50% of familial acromegaly. AIP-related PA are GH, PRL-secreting or non-secreting. Little is known about AIP expression in PA. Although the prevalence is low, identifying AIP mutations in apparently sporadic PA is important for studying at-risk relatives. Pre-screening criteria would help select ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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