Endocrine Abstracts

Adult GHD patients may have reduced BMD with high risk of vertebral and non-vertebral fractures which is thought to be reverted by long-term rhGH replacement therapy. In this study we aimed at identifying the determinant factors of vertebral fractures, as assessed by a radiological morphometric approach, in a cohort of adult patients with untreated GHD. Forty-two patients (27 males, 15 females; median age: 48 years, range: 30–67) with untreated severe (as defined by a pea...

Adult GHD patients may have reduced BMD, which is thought to be reverted by long-term rhGH replacement therapy. We have recently reported high prevalence of vertebral osteoporotic deformities in untreated adult GHD patients. Gonadal status is the main determinant of bone loss in patients with primary form of osteoporosis.In this cross-sectional study, we investigated whether the prevalence and degree of spinal deformities in adults with treated or untrea...

Background: Primary empty sella (ES) can be asymptomatic or associated with endocrine and neurological alterations, such as visual defects. Studies in a large number of patients is still lacking.Objective: To study visual deficit in ES and its relationship with hormonal status.Material and Methods: We recorded visual evoked potentials (VEP) by white/black, red/black, blue/black patterns. Isoluminance between red and blue checks all...

In order to investigate the correlations between immunohistochemical picture with proliferative index (Ki-67), the clinical course and outcome of GH-secreting pituitary adenomas not cured by neurosurgery, we studied 41 consecutive acromegalic patients (M 12, F 29; aged 43±10.8 yr) previously undergone neurosurgical resection of adenoma. Two patients underwent neurosurgical intervention at least twice. Post-surgical follow-up ranged from 6 to 36 months and all patients rec...

Background: Immune checkpoint inhibitors (ICI) have become a clinically validated treatment for numerous types of tumor including melanoma, lung, and kidney carcinoma. These treatments can cause immune-related adverse events affecting several organs including the endocrine system.Aims: The aim of this study was to characterize the type and the onset of the ICI associated-endocrinopathies.Materials and methods: This retrospective co...

Introduction: Diabetic ketoacidosis (DKA) is a feature of type 1 diabetes mellitus, but it can develop in people with type 2 diabetes (T2DM) in the presence of precipitating factors. Antipsychotics have been associated with pancreatitis without DKA or hyperglycemia or acidosis with no evidence of pancreatitis. To our knowledge, there are few reports of patients who developed pancreatitis and DKA during treatment with antipsychotis. We present a case of a patient who developed ...

IntroductionPrimary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs.Material and methodsSerum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey h...

Tumor-induced osteomalacia (TIO) or ‘oncogenic osteomalacia’ is a rare paraneoplastic disorder, usually resulting from Fibroblast Growth Factor 23 (FGF23) oversecretion by a benign small ‘phosphaturic mesenchymal tumor’, causing hypophosphatemia and reduced 1,25-dihydroxyvitamin D synthesis. Calcium and parathyroid hormone (PTH) levels are usually normal, but secondary/tertiary hyperparathyroidism has been reported in up to 5% of the cases, mainly due to 1,...

Introduction: First-generation SRL (fg-SRL) represent the treatment of choice in acromegaly patients with post-neurosurgical adenomatous remnant and GH-hypersecretion. Anyway, approximately 60% of patients do not achieve adequate disease control. The main predictors of resistance include male sex, young age, invasiveness of the lesion and its hyperintensity on T2-weighted MRI scans; but also, SSTR2 expression, the cytokeratin pattern, Ki-67 and the presence of AIP gene mutatio...

Introduction: Acromegaly patients (ACRO) show increased morbidity that affects health and quality of life (QoL). Elderly ACRO are going to increase in the next few years, but evidence regarding their management is lacking.Aim: To evaluate physical, functional and cognitive performances of elderly ACRO and the relationship with QoL.Methods: Multicenter case-control study conducted on 42 older ACRO (≥ 65 years) compared to an a...