Endocrine Abstracts

Amyotrophic lateral sclerosis (ALS) is the most common motor neurone disorder in human adults. Scanty data on endocrine abnormalities have been reported. Aim of the present study was to investigate the GH-IGF-I axis in ALS patients.22 ALS patients (12 men and 10 women), aged 46–77 years, performed GHRH+arginine test: blood samples for GH were collected at baseline, 30 and 60 minutes; IGF-I was determined at baseline. The control group consisted of 2...

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...

First TBSRTC editions have made advances in problems of thyroid management. However, the real grey zone ‘AUS/FLUS’ and ‘FN/SFN’categories have been remained to be problematic with the wide range of ROMs documented in the literature alongside two editions. The ROMs of ‘AUS/FLUS’ and ‘FN/SFN’ categories were defined as 5-15% and 15-30% and the management was ‘repeat FNA’ and ‘lobectomy’ -respectively- in the first editi...

Background: Graves’ disease (GD) typically manifests as an autoimmune hyperfunction of both thyroid lobes. Less than 10 cases of unilateral GD have been described, and the pathophysiology of unilateral GD remains unknown. Co-existence of malignancy has never been reported. We report a case of GD of the left lobe with simultaneous discovery of a papillary carcinoma within the hyperfunctioning lobe.Case description: A 49-year-old patient of Middle-Eas...

Background: KEAP1 gene (Kelch-like ECH-associated protein 1) that encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses, has been found to be one of the mutated genes that lead to familial multinodular goiter (MNG). The proposed association of KEAP1 with familial MNG is based on only two loss-of-function mutations in respective Japanese families. To date, there is no experim...

Introduction: The pseudo-Cushing’s encompass several disorders that can occur in high-stress situations, such as the sepsis, and that show biochemical features like those of Cushing’s syndrome. We present a case with difficult differential diagnosis, for overlapping laboratory findings.Case description: A 74-year-old man was admitted to our hospital for worsening dyspnoea since a month, 15 kilograms weight loss in the previous months, asthenia,...

Introduction: Alzheimer disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose homeostasis alterations observed in AD patients. However, the links between tau impairments and glucose homeostasis, remains unclear.Objective: In order to better understand the links between tau and gl...

Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined on a large cohort.Objective: In this study, we aimed to first establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Secondly, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters....