Endocrine Abstracts

Infertility affects milions of couples worldwide. Determining the exact cause represents a real challenge and may require a complex work-up.Objective: To asses the main etiological factors of female infertility and the best treatment.Methods: Retrospective study which included 150 women diagnosed with infertility in a Romanian tertiary center. The median age was 30.5 years (20–41), 65.3% (n=98) of the patients were di...

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

Thymic hyperplasia is frequent in patients with Graves’ disease (GD) but it rarely is large enough to be detected radiologically as an anterior mediastinal mass. In the few cases operated, lymphoid hyperplasia (i.e. lymphoid follicle proliferation with expansion of both the cortical and the medullary component) has been documented histologically in 38% of cases, while true thymic hyperplasia, i.e. thymic enlargement with normal tissue architecture, was found...

Background: Growth hormone directly stimulates tumour growth, angiogenesis and metastasis through autocrine and paracrine effects on cancer cells, while through IGF1 inhibits apoptosis and promotes epithelial proliferation. Although disputed, some studies have shown an increased cancer incidence in acromegaly patients, especially in uncontrolled subjects, while others have not.Aim: To assess prevalence of cancer in a cohort of patients with long term tre...

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Standard treatment includes thyroidectomy (extention depending on tumour size, pathology and lymph nodes involvement). If indicated, radioiodine therapy after TSH stimulation either by levothyroxine withdrawal or rhTSH administration is recommended. In patients with thyrotropin deficiency rhTSH administration is mandatory.Case report: A 30-year-old woman, resident in...

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid neoplasm with a high degree of malignancy derived from the parafollicular calcitonin-secreting cells. This carcinoma may occur sporadically in about 80% of cases or it may be part of the autosomal dominant multiple endocrine neoplasia (MEN) type 2. While the 10-year survival rate is around 40–75%, for metastatic disease, it’s just below 20%.Case presentation: We report the case of ...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the postsurgical evolution of craniopharyngioma in adults after total or incomplete surgical resection.Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Buc...

Introduction: Riedl thyroiditis is a rare thyroid disorder of unknown etiology (autoimmune assumed), in which the gland is invaded by dense fibrous tissue, that extends in the vicinity. Goiter is usually painless and can be accompanied by other fibrous affections (retroperitoneal fibrosis, sclerosing cholangitis, mediastinal fibrosis).Case presentation: Patient, 39 years old, smoker, from nonendemic area, initially presents in 2011 with voluminous polyno...

Introduction: Progressive osseous heteroplasia (POH) is a rare genetic condition of progressive heterotopic ossification (HO), from skin and subcutaneous tissues into deep skeletal muscles. Most cases are caused by heterozygous inactivating mutations of GNAS gene. Related disorders are Albright hereditary osteodystrophy (AHO), pseudohypoparathyroidism (PHP), and primary osteoma cutis. Distinction from other GNAS-based conditions is made by the extension of HO from superficial ...

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...