Endocrine Abstracts

Since the advent of effective combined antiretroviral therapy (ART), mortality due to HIV disease has significantly declined. Changing trends in HIV-associated morbidity is surfacing, firstly due to the effect of HIV on virtually every human organ system and secondly due to improved life expectancy and consequent development of natural co-morbid illnesses. HIV associated endocrinopathies and metabolic diseases pose a significant disease burden in these patients. We discuss thr...

Background: Mullerian agenesis or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a congenital failure of the Mullerian duct to develop, resulting in complete or partial absence of the cervix, uterus, and vagina. It can be isolated (MRKH type I) or associated with renal, vertebral, and, to a lesser extent, auditory and cardiac defects (MRKH type II). Pituitary disease is not a known association. We report a patient who has isolated MRKH syndrome (MRKH type I) and a pituitary...

Aim: Malabsorptive bariatric procedures lead to significant metabolic improvement with ongoing weight loss. The aim of our retrospective analysis was to assess the impact of bariatric surgery on three important metabolic and biochemical abnormalities associated with obesity: diabetes, liver function test (LFT), and dyslipidaemia.Methods: All patients who had laparoscopic gastric bypass (LGB) or sleeve gastrectomy (SG) over the last 7 years were identifie...

Introduction: Interpretation of renal function in patients with obesity and post-bariatric surgery is a clinical challenge. EGFR could be falsely low and weight loss does not reflect muscle mass. The aim of our study was to compare the fluctuations in renal function assessment in patients undergoing bariatric surgery.Methods: 200 patients who underwent bypass surgery or sleeve gastrectomy were analysed. Six different renal function parameters were analys...

Background: Childhood and adolescence are critical periods for the establishment of lifelong bone health. While most studies focus on vitamin-D regardless of PTH levels, Normocalcemic Primary Hyperparathyroidism (NPHPT) has been recognized more than 15 years ago as a variant of primary hyperparathyroidism (PHPT), characterized by persistently elevated PTH with normal albumin-adjusted total and ionized calcium, in the absence of secondary causes of hyperparathyroidism. PPHPT is...

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

Introduction: Vitamin D deficiency is common in ethnic minority population living in UK. It is a relatively easily treatable condition. However, if left untreated it may lead to chronic secondary hyperparathyroidism and onto tertiary hyperparathyroidism. We report three cases of severe vitamin D deficiency who presented with hypercalcaemia.CasesWe report three patients. 60 and 46 years old ladies, both of south-asian origin, a 46 y...

We report potential effects of antituberculosis (TB) treatment on vitamin D metabolism in the immediate postoperative period following total thyroidectomy.A 50-year woman of Chinese origin was incidentally found to have papillary thyroid carcinoma with local nodal metastasis following FDG–PET imaging done to assess nature of lung nodules on chest X-ray and CT chest. The nature of lung lesion was uncertain and commenced on empirical TB treatment (fou...

Background: An effective care pathway is required for the smooth ‘transition’ (rather than swift ‘transfer’ of care) from the paediatric to adult diabetes clinic. Engaging the patient in the service, with a clear, smooth and robust pathway, is required to bridge this very challenging period. The aim of our study was to assess the effectiveness of a staged transition process based on a shared-care protocol that has been existent over the last 3 years at our ...

Hypothesis: Exogenous kisspeptin-10 (Kp10) enhances pulsatile LH. Research strategy: A first-in-man dosing study of kp10 was first performed. Healthy volunteers and hypogonadal patients were subsequently infused with kp10. Dose titration study Rapid increases in LH with clear dose-dependency (P<0.0001) were observed in healthy men (n=6), with the 0.3 and 1 µg/kg doses being maximally stimulatory (P<0.01). Effect of sex-steroid milieu: LH respo...