Endocrine Abstracts

Glucocorticoid hormones (cortisol in man, corticosterone in rodent; CORT) are vital for maintaining normal homeostasis in multiple systems ((e.g., the cardiovascular, metabolic, and immune systems), and for an optimal response to acute and chronic stress. Plasma CORT is released from the adrenal zona fasciculata (ZF) in response to circulating levels of pituitary-derived adrenocorticotropin hormone (ACTH). ACTH binds to the MC2-receptor on the membra...

A 74 years old man prsented with gradually worsening confusion with associated jerky movements with background of well controlled type 2 Diabetes, CKD-3, IHD and previous duodenal ulcer. His was on Finasteride, Omeprazole, Mirtazapine, Tamsulocin, Metformin, Atorvastatin, Humulin I insulin. He was taking omeprazole for Duodenal ulcer since 1993.On examination he had jerky movements of the arms suggestive of muscles spasms. Res...

Introduction: Hypercalcaemia is a common electrolyte disturbance in patients presenting acutely and can be cause or effect of a multitude of disorders. We present four cases, in which the hypercalcaemia masked or unmasked underlying pathology that may have otherwise gone undiagnosed.Case series: A 36-year old man presented with acute pancreatitis after completing a marathon. Bloods: adjusted calcium (cCa) 3.16 mmol/L, phosphate 0.5...

FSH and its G protein-coupled receptor (FSHR) are essential for the coordination of reproductive functions. As such, they are a primary target of most assisted reproductive technologies, thus understanding the physiology regulating their function is paramount. Two naturally occurring glycoforms of FSH have been identified-hyperglycosylated FSH (FSH24) and hypoglycosylated FSH (FSH21), based on their ASN glycosylation pattern. The secretion of FSH21 and FSH24 has been shown to ...

Glucocorticoid hormones (cortisol in man, corticosterone in rodent; CORT) are vital for maintaining normal homeostasis in multiple systems ((e.g., the cardiovascular, metabolic, and immune systems), and for an optimal response to acute and chronic stress. Plasma CORT is released from the adrenal zona fasciculata (ZF) in response to circulating levels of pituitary-derived adrenocorticotropin hormone (ACTH). ACTH binds to the MC2-receptor on the membra...

A 74 years old man prsented with gradually worsening confusion with associated jerky movements with background of well controlled type 2 Diabetes, CKD-3, IHD and previous duodenal ulcer. His was on Finasteride, Omeprazole, Mirtazapine, Tamsulocin, Metformin, Atorvastatin, Humulin I insulin. He was taking omeprazole for Duodenal ulcer since 1993.On examination he had jerky movements of the arms suggestive of muscles spasms. Res...

Introduction: Hypercalcaemia is a common electrolyte disturbance in patients presenting acutely and can be cause or effect of a multitude of disorders. We present four cases, in which the hypercalcaemia masked or unmasked underlying pathology that may have otherwise gone undiagnosed.Case series: A 36-year old man presented with acute pancreatitis after completing a marathon. Bloods: adjusted calcium (cCa) 3.16 mmol/L, phosphate 0.5...

Objective: The performance of two functional bioassays and two immunoassays for the measurement of TSHR-Ab was assessed in this multicenter study.Methods: Two-hundred two subjects (median age 54 years, 162 female, 80%), with well-documented thyroid disorders and controls were prospectively enrolled in a consecutive, unselected manner. Antibody measurements were performed in a blinded manner using the Bridge (Siemens, performed at the Dartmouth-Hitchcock ...

Objectives: Teprotumumab, an IGF1-receptor antagonist, has been shown in three clinical trials to markedly improve the clinical course of Thyroid Eye Disease (TED) or Graves’ Orbitopathy (GO) with significant improvements noted in inflammation, proptosis, and diplopia. Furthermore, compared to placebo moderate-to-large improvements were noted in the total, appearance (AP), and visual function (VF) as measured by EUGOGO GO quality of life (GO-QOL) scores after 24 weeks of ...

G protein-coupled receptors are the largest family of mammalian receptors, with key roles in controlling most physiological processes. Ovarian function is no exception, with a key ovarian GPCR, follicle stimulation hormone receptor (FSHR), and its endogenous ligand, FSH, critical for pre-antral-antral follicle growth and survival. An increasingly important way that GPCRs have been shown to regulate ligand specificity and signal amplitude is via association and formation of dim...