Endocrine Abstracts

Non-alcoholic fatty liver disease NAFLD has been associated with androgen deficiency, yet in the majority of patients with non-alcoholic steatohepatitis NASH, androgens levels are normal. In contrast, women with polycystic ovarian syndrome PCOS, which is characterised by androgen excess, have evidence of increased liver fat. Our hypothesis is that androgen exposure to the liver may be crucial in the amount of lipid that can accumulate in hepatocytes. C3A human hepatoma cells w...

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP),...

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

Primary hyperparathyroidism (P-HPT) is one of the most common of all endocrine disorders. 80 to 85% of cases are due to parathyroid adenomas while hyperplasia accounts for 10% to 15% and carcinoma less than 1%, of cases.1 Its very rare for parathyroid adenoma to present with clinically severe hypercalcaemia or a ‘parathyroid crisis’. There are some existing case reports.2,3 We report a case of a 67 year old woman who presented with severe irrita...

Introduction: A growing body of evidence is supporting a beneficial impact of breastfeeding on maternal metabolism and overall cardiovascular risk. The aim of this study was to evaluate the association between prolactin levels and metabolic parameters as well as indices of subclinical atherosclerosis, in a sample of premenopausal women with normal levels of prolactin.Patients and Methods: This cross-sectional study included a total of 64 non-lactating pr...

Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the commonest cause of liver cirrhosis and leading indication for liver transplant worldwide. It is tightly associated with obesity and type 2 diabetes, yet the precise mechanisms that drive its aetiology are not fully defined. Dysregulation of both glucocorticoid and androgen metabolism has been implicated in its pathogenesis. The availability of these hormones to bind and activate their receptors is mainly regulat...

Introduction: Prenatal and perinatal food manipulation might be related with bone quality in offspring of Wistar rats. This study aimed to assess the impact of different dietary patterns provided before delivery to the mothers on the skeletal characteristics of newborn rats and the levels of insulin.Materials and methods: We randomized 67 timed-pregnant rats into control diet (CD), high-fat (FD) and food-restricted (FR) on the 12th day of gestation. The ...

Introduction: Metabolic syndrome and cardiovascular disease (CVD) are well-known long-term implications of the menopausal transition. Lifestyle practices like exercise could potentially act protective with regards to future cardiovascular risk at midlife. We aimed to assess the impact of physical activity on the development of subclinical CVD in postmenopausal women, adjusting for the effect of underlying obesity.Methods: This cross-sectional study from ...