Endocrine Abstracts

Introduction: Obesity-associated psychopathological co-morbidities have a negative impact on quality of life. Roux-en-Y gastric bypass surgery (RYGB) has been shown to ameliorate psychological health, however, the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following RYGB. Here we assess the impact of subcutaneous infusions of th...

Metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), are increasing in prevalence. Steroid hormones are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human liver, inactivating steroid hormones, including glucocorticoids and androgens. The human AKR1D1 gene contains 9 exons; six splice variants have been identified and three lead to functional protein isoforms (AKR1D1-001, -0...

Background: A growing body of evidence reports implications of a direct extra-gonadal effect of follicle stimulating hormone (FSH), involving the development of obesity. The aim of this study was to evaluate the associations between traditional and local obesity indices and FSH concentrations in women after menopause.Methods: We evaluated a total of 420 postmenopausal women in a cross-sectional design (age 55.6±6.5 years, BMI were 25.8±4.0 kg/m...

Introduction: Hirsutism affects 10% of the female population caused by hyperandrogenism of benign aetiologies or androgen-secreting tumours. Tumorous causes of hyperandrogenism include androgen producing ovarian or adrenal tumours. Leydig cell tumours are rare ovarian testosterone producing tumours that comprise 0.1% of total ovarian tumours. It is rare in postmenopausal women and present with features of hyperandrogenaemia or hyperestrogenemia.Case: We ...

Objective: Aiming to identify individuals with more benign metabolic profile, we explored the link between anthropometric predictors as well as serum levels of sex hormones and phenotypes of metabolic health in non-obese postmenopausal women.Methods: A total of 458 non-obese (BMI <30 kg/m2) postmenopausal women (age 55.2±7.1 years, BMI=24.6±2.8 kg/m2) were retrieved from the Menopause Clinic of Aretaieio Hospital, Nati...

Background: Metastatic pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine neoplasms with a <1:106 incidence, defined by the presence of metastatic disease besides recurrent or locally invasive disease.Aim: Retrospective analysis of clinical, biochemical/hormonal, imaging, genetic and histopathological features of patients with malignant PCs/PGLs diagnosed over 15 years.Results: Thirteen patient...

Background: Dysmenorrhea is defined as pain during menstruation and might be caused by increased endometrial prostaglandin production. It is a highly prevalent medical condition (45–95% of women internationally) which can be part of a woman’s reproductive life. Throughout the literature, dysmenorrhea has been shown to affect daily functioning such as socialization, work and academic performance during menstruation and quality of life. However, dysmenorrhea and its im...

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

Introduction: Although computed tomography (CT) is the best mean to identify adrenal neoplasms there is still controversy of the concordance of the estimated radiological and histological size of the lesion. Since the size of adrenal tumours is a major criterion for surgical excision, we investigated whether recent and more sophisticated imaging techniques, can more accurately predict tumor’s size.Methods: We have retrospectively analyzed a series o...

Numerous studies have identified several extra-skeletal health outcomes to be associated with vitamin D deficiency, yet a definitive causal link is yet to be discovered. Our recent 3D LC-nESI-FTMS proteomic analysis among normal and overweight but apparently healthy adult Saudis identified apolipoproteins, a known independent cardiovascular risk factor, as one of the serological molecular signatures that modulate vitamin D levels. The present interventional study aims to compa...