Endocrine Abstracts

Objective: To investigate the frequencies of three paraoxonase (PON)1 polymorphisms in Greek polycystic ovary syndrome (PCOS) and non-PCOS women, and their genotypes in association with hyperandrogenemia and insulin resistance.Design: Case–control genetic association study.Patients: PCOS cases (NIH criteria) and 112 controls.Main outcome measure: Genotyping of the c.−108C>T (PON1-108), the c.16...

Introduction: Thyroid storm is a rare condition, reflecting an extreme physiological state within the spectrum of thyrotoxicosis. The disorder consists of the clinical manifestations of thyrotoxicosis in association with altered mental status. On the other hand, excess circulating thyroid hormones are associated with glycemic disorders, like hyperglycemia and insulinopenia. Moreover, diabetic ketoacidosis has been associated with thyroid storm in few cases. We report the case ...

Introduction: FNA cytology are done for solitary nodule or a dominant nodule in MNG.FNA classified in 5 groups (THY1 to THY5). FNA labelled as THY1 and THY2 should have repeat FNA. We have studied the FNA cytology over the period of 5 years. They are done in clinical settings by physician, surgeon or radiologist. Aim: To assess the trust practice of FNA cytology in Thyroid swelling and compare them with standards.Methods: Data were collected from patholo...

Introduction: Malignancies and hyperparathyroidism account for over 90% of cases of hypercalcaemia. When presenting with suppressed PTH, malignancy is its commonest cause. We present a case of PTH-independent hypercalcaemia of immobilisation responding to bisphosphonate therapy.Case summary: A 57-year-old Caucasian male presented with significant weight loss and severe back pain. He consumed 50 units of alcohol a week, had stopped smoking 20 years earlie...

The existence of the principle of hypothalamic hypophysiotropic factors, predicted so prophetically by G W Harris in the 1940’s, has been confirmed by irrefutable evidence. This principle is central to the survival of complex organisms as both individuals and species. Life exists through maintenance of a complex dynamic equilibrium, or homeostasis, that is constantly challenged by intrinsic or extrinsic adverse forces, or stressors. Thus, stress is defined as a state of t...

Cellular transplantation has enormous potential for treating a variety of degenerative or malignant conditions. While adult stem cells display limitations in expansion capacity and developmental potential, embryonic stem (ES) cells are an inexhaustable source of tissues for research and therapy. During the last decade, human ES cells have been isolated, and differentiated to several tissue-specific progenitors. In vitro differentiating ES cells recapitulate early steps ...

Introduction: About 3% of patients treated with amiodarone develop thyrotoxicosis (amiodarone induced thyrotoxicosis, AIT). Steroids and carbimazole are the main treatment options with surgical thyroidectomy performed in resistant cases. Radioiodine is believed to be unhelpful based on presumed poor radioiodine uptake by thyroid tissue saturated with iodine. We present a case of AIT with a low technetium uptake being successfully treated with radioiodine ablation.<p class=...

A 30-year-old female presented to accident and emergency having been found collapsed. The patient had a reduced Glasgow Coma Scale of 10, was pyrexial, clinically in shock and pale in colour. Initial investigations confirmed hypoglycemia and a metabolic acidosis. A collateral history described a 3 days history of diarrhoea. Her 5-year-old child (who was conceived normally) also had diarrhoea.The impression was of shock secondary to sepsis and hypovolemia...

We report the cases of two identical twins with Graves’ disease which proved very difficult to control and followed very similar stormy course. Twin A was a 20 years old female of 12 weeks gestation when she was referred to endocrine clinic with history of weight loss, palpitations and tremor. Her thyroid function tests revealed TSH <0.08 mU/L (0.03–4.30), FT4 82.5 pmol/L (12–22 pmol/L) and FT3 44.4 pmol/L (2.8–7.1) with positive thyroid receptor antibo...

Section 1: Case history: A 53 year old male of Chinese ethnicity presented to hospital with a fall and a long lie. He had a heavy meal for dinner, and he fell later in the evening after standing from the sofa. He lacked strength in his limbs and could not stand up again. He was on the floor for 7 hours before he could shuffle his way to the phone and call for help. On examination he had MRC grade. power in the proximal arms and MRC grade. hip. flexion. Sensation was normal. He...