Endocrine Abstracts

Parathyroid carcinoma (PC) rarely presents with metastasis at diagnosis and usually in patients also having gross local invasion.Case presentation: We report the case of a 51-year-old postmenopausal woman presenting at our institution in June 2019 with symptomatic hypercalcemia (fatigue, polyuria, constipation and bone pain), but with a surprisingly good general condition. She had been treated with bisphosphonates for osteoporosis (DXA: LS T score &#8722...

Objectives: Mean TBS (Trabecular Bone Score) values are generally lower in PHPT (primary hyperparathyroidism) patients than controls. The aim of this study was to assess TBS from spine DXA images in patients with PHPT and look at its correlates.Methods: This was a cross-sectional study conducted in an osteoporosis referral center. One hundred and thirty six patients with PHPT were selected from our database (2010–2016) if they had a valid LS DXA sca...

Introduction: Successful parathyroid surgery in patients with OFC leads to early and marked improvements in BMD but data on very early changes in bone markers are missing.Case report: A 20-year-old girl was hospitalised because of severe bone pains and multiple pathological fractures (left humerus and left proximal femur) after minimal trauma. She had lost weight, was amenorrhoeic for the last 12 months and was bleeding from brown tumours in her mouth. S...

Introduction: Complete long-term clinical remission in occult ectopic ACTH syndrome after a single adrenalectomy is unexpected.Case report: 5 year ago, a 54-year-old man was admitted because of resistant HTA, multiple severe vertebral fractures, muscle weakness and cushingoid features of at least 1 year. Adrenal tests were diagnostic of ACTH-dependent Cushing’syndrome: ACTH=263 pg/ml, high plasma (62 μg/dl) and urinary free cortisol (UFC=1256 &...

Introduction: Pituitary apoplexy is a rare acute complication in patients with functioning pituitary adenomas (including acromegaly) often followed by hypopituitarism and occasionally may show remission of symptoms after an apoplectic episode. We report this in an acromegalic patient who developed remission following pituitary apoplexy.Case report: A 24 years old woman is diagnosed with acromegaly after presenting for a period of 6 months moderate headac...

The oral dosing with cholecalciferol needed to achieve and maintain optimal serum concentration 25-hydroxyvitamin D (25OHD) is still controversial.This study reports on the efficacy of supplementation with oral vitamin D3 1000 U/day for 3–18 months on serum 25OHD levels in 87 ambulatory patients with postmenopausal osteoporosis (mean age 63.5 years). Serum 25OHD, parathyroid hormone (PTH), calcium (serum, urine), phosphate, alkaline phosphatase and ...

The nitrogen-containing bisphosphonate Risedronate have been shown to reduce the risk of both spine and nonspine fractures by reducing bone turnover, increasing bone mass and improving bone strength.Objective: To study the effects of once-weekly Risedronate on bone turnover markers in osteoporotic patients after three month of treatment.Patients and methods: Study group included 50 osteoporotic patients (3 males and 47 females), me...

The nitrogen-containing bisphosphonate Risedronate have been shown to reduce the risk of both spine and nonspine fractures by reducing bone turnover, increasing bone mass and improving bone strength.Objective: To study the effects of once-weekly Risedronate on bone turnover markers in osteoporotic patients after three month of treatment.Patients and methods: Study group included 50 osteoporotic patients (3 males and 47 females), me...

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of chronic hypophosphatemia caused by the production of FGF23 in a typically small, benign, mesenchymal tumor. The diagnosis is often delayed and finding the tumor is sometimes challenging. We present a case of a 50 yrs old woman with TIO, referred to our clinic for progressive muscle weakness, diffuse bone pain and fractures, extensively investigated for 3 years. 2 years before admission she had a vertebroplas...

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...