Endocrine Abstracts

IntroductionClinically functioning gonadotroph adenomas (FGA) are rare, especially in men. We present a case of a LH/FSH-secreting functioning gonadotroph macroadenoma in an elderly patient, which manifested with visual impairment and was accompanied by secondary erythrocytosis.Clinical caseA 62-y.o. male was admitted to our hospital with a 9-month history of visual impairment and a 5-year history of plethora...

Objectives: To assess the frequencies of hyponatremia and central diabetes insipidus (CDI) after transnasal adenomectomy and to identify its risk factors.Patients and methods: The study included 152 patients aged 18 to 65 years (median [Q1; Q3] 40 [31; 52]) who underwent endoscopic endonasal transsphenoidal surgery due to Cushing’s disease, acromegaly, prolactinoma, non-functioning pituitary adenoma, thyreotropinoma or Nelson’s syndrome at Endo...

Introduction: Water-electrolyte disorders are serious complications after transnasal adenomectomy for formations of the hypothalamic-pituitary region. The purpose of this work was to evaluate the incidence of postoperative hyponatremia in the tactics of active control of sodium levels in the blood.Materials and methods: The study included the results of a dynamic study of blood sodium levels in 53 patients (mean age 46.6 years [min 19; max 68]) with pitu...

Multiple endocrine neoplasia type 1(MEN1) is a hereditary condition caused by mutations in the MEN1 gene, which encodes menin protein. The syndrome predisposes to the development of tumors in both endocrine and non-endocrine systems. In patients with MEN1, pituitary adenomas (PA) occur in approximately 40% of all cases. If patient has MEN1 phenotype with no mutations in MEN1 gene, the condition is regarded as a phenocopy. The reason of several endocrine MEN1-...

Introduction: According to recent studies, fluid and electrolyte disturbances complicate the course of transnasal adenomectomy for pituitary adenomas in 13–30% of cases and are associated with a high risk of neurological complications and increased mortality. Neuropeptides discovered in recent decades (apelin, copeptin, oxytocin, brain natriuretic peptide) in many studies demonstrate their significant effect on the regulation of water-electrolyte metabolism, which makes t...

Objective: To estimate the outcome of neurosurgery in patients with Cushing’s disease (CD) with and without pituitary adenoma visualisation on MRI.Material and methods: Patients with confirmed CD (11.2008–11.2014) by both inferior petrosal sinus sampling (IPSS) and histological evaluation after neurosurgery were enrolled into the study. Subjects were referred for IPSS because of non-visualised pituitary adenoma or contradictory results of non-i...

The course and predictors of postoperative diabetes insipidus.Objectives: To evaluate the course and predictors of permanent and transient postoperative diabetes insipidus (DI).Patients and Methods: The study included 152 patients undergoing endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40. 73 patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inacti...

Introduction: Hungry bone syndrome (HBS) is a rare condition that can appear after surgery for hyperparathyroidism, characterized by hypocalcemia, hypophosphatemia, low calciuria, especially in patients with severe primary hyperparathyroidism, bone lesions and elevated alkaline phosphatase. We present a case of severe persistent hypocalcemia after resection of a giant parathyroid adenoma in a patient with concurrent osteoblastic bone metastasis from prostate cancer.<p clas...

Introduction: Multiple endocrine neoplasia type 2A is an autosomal dominant disorder which is characterized by the occurrence of medullary thyroid carcinoma in association with pheochromocytoma and parathyroid tumors.Case report: We present the case of a 64-year-old woman, with familial history of thyroid carcinoma, renal lithiasis and personal history of right nephrectomy for renal lithiasis, who presented for the investigation of a left lateral cervica...

Introduction: Clear cell renal carcinoma (ccRCC) is a subtype of renal cell carcinoma, the most frequent one (80%) and usually affecting only one kidney. It is twice as common in men than women between 50 to 70 years old. It can be associated with some genetic conditions that predispose patients to ccRCC, like Von Hipple-Lindau disease. Some clinical observations and molecular studies raised the hypothesis that RCC is a hormone−dependent tumor.Case...