Endocrine Abstracts

Introduction: The association between autoimmune diseases, including systemic lupus erythematosus (SLE), and endogenous hypercortisolism is rare. The latter is usually misinterpreted as iatrogenic in the case of patients taking exogenous systemic corticosteroid therapy. The excess endogenous glucocorticoids may play an important role in suppressing autoimmune activity. Similarly, the abrupt resolution of endogenous hypercortisolism may lead to a rebound worsening of autoimmuni...

Introduction: Androgen-producing tumors are a rare cause of hyperandrogenism (±0.2%). Ovarian steroid cell tumors represent <0.1% of all ovarian tumors. They may present at any age and in 12–50% of cases are associated with virilization. The majority of these tumors are benign or low-grade malignanies.Clinical case: A 74-year-old female patient, with history of vaginal hysterectomy for genital prolapse at the age of 50, is referred to Endoc...

Cushing’s syndrome is a rare disorder in children and adolescents. The diagnosis can be a challenge for the clinician, as its principal feature – obesity – is extremely common. We present three cases diagnosed in the last 20 years. The first one was a boy aged 17 that presented in 1984 with central obesity, acne, moon face with plethora, abdominal striae, easy bruising and skin atrophy. The investigations performed consisted in cortisol and ACTH plasma measureme...

Thyroid hormones (TH) are responsible for maintaining metabolism. Its concentrations are fundamental during pregnancy and the first days of life, and its imbalance can generate early and late repercussions for the newborn.Objectives: This study evaluates the relationship between maternal thyroid disease history impact on newborns and infants admitted to the semi-intensive care unit.Materials and methods: Data were collected from a ...

Introduction: The development of new pharmacological classes for type 2 diabetes (T2D) treatment with extra-glycaemic benefits has led to the update of the treatment algorithm, presenting new effective alternatives to patients’ insulinization. The present study aims to evaluate the evolution of prescription and its impact in metabolic control of patients enrolled on an educational diabetes program of a tertiary hospital.Objectives: To evaluate trend...

Aim: To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and also correlate the findings with serum insulin, leptin and HOMA-IR.Methods: A cross-sectional study with thyroid ultrasound and serum glucose, insulin, leptin and TSH was performed with obese patients and a control group without known thyroid diseases, matched for age and sex, but with BMI of <25 kg/m2.Results: Twent...

Obesity is a chronic multifactorial disease characterized by accumulation of body fat and is associated with a number of comorbidities, such as diabetes and cardiovascular disease. The treatment of obesity depends to the severity of the disease, however, healthy eating with caloric restriction and physical activity are important strategies. In the present study, we aimed to evaluate the effect of obesity associated with strength training on skeletal muscle morphology, body adi...

Introduction: The association of fasting glucose (FG) in early pregnancy (EP) with adverse outcomes for the mother and her offspring is well known, although the best cut-offs for diagnosis of Gestational Diabetes (GD) are not consensual.Objetive: Evaluate the impact of FG in EP in the management of pregnant women and obstetric and fetal outcomes.Methods: Retrospective cohort of pregnant women with GD diagnosed before 24 weeks of ge...

Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy, leading to adverse neonatal and obstetric outcomes.Objective: To evaluate the influence of maternal prepregnancy body mass index (BMI) on blood glucose levels at diagnosis of gestational diabetes (GD), obstetric and neonatal outcomes.Methods: Retrospective observational study including women with GD and singleton pregnancy, with fo...

Introduction: The American Diabetes Association guideline states that the long-term use of metformin may be associated with biochemical vitamin B12 (B12) deficiency and periodic measurement should be considered, although isolated serum B12 measurement has low sensitivity and specificity. Homocysteine (Hcy) and methylmalonic acid (MMA) are more sensitive biomarkers, the latter being more specific.Objectives: To estimate B12 deficiency in type 2 diabetics ...