Endocrine Abstracts

Background: Craniopharyngioma (CP) are the most common sellar tumors in children. Patients often develop excessive weight gain and obesity due to several factors as involvement or damage of the hypothalamus. Previous studies on the weight development in craniopharyngioma patients have shown an increase in weight before and in the first 10 years after diagnosis leading to an impaired quality of life. The long-term weight development in these patients has not been investigated t...

Background: SUB:Pituitary – Clinical (Generously supported by IPSEN)Hypothalamic involvement (HI) resulting in severe obesity is known to have major impact on quality of life in craniopharyngioma (CP) patients. HI is also associated with disturbances of satiety regulation leading to a failure to thrive and weight loss known as diencephalic syndrome (DS). The rate of DS and the outcome of CP patients with DS is unknown.Methods: CP patients h...

Background: Recent data suggest a direct impact of ghrelin and leptin on the immune system. Ghrelin appears to antagonize these effects. The role of ghrelin and leptin in the context of ANCA-associated vasculitis (AV) has not been reported.Methods: Fasting serum ghrelin, free and bound leptin levels were measured in 44 patients with active AV and 25 in matched healthy controls. Follow-up under immunosuppressive therapy was available in 25 patients (1, 3,...

BackgroundData on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare.Study designObservational study on pregnancy rate and outcome of offspring after CP in postpubertal, female patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000.Results451 CP patients (223 female) have been recruited. 269 CP patients...

Background: It is well known that both genetic backgroup and lifestyle influence the development of ‘general’ obesity. However, the role of parental body mass index (BMI) on the development of obesity in long-term survivors of childhood-onset craniopharyngioma (CP) is not well understood. This study aimed to analyze the correlation of patients’ BMI at diagnosis, and last visit and parental BMI at CP diagnosis and further explored potential risk factors for obesi...

Background: Proton beam therapy (PBT) compared to photon-based radiotherapy (XRT) offers the benefit to administer lower radiation doses to critical organs thereby possibly minimizing the risk of sequelae in patients with residual craniopharyngiomas (CP) after hypothalamus-sparing surgery. The validation in large CP patient cohorts is still pending. Methods: Of 290 childhood-onset CP patients included 2007-2019 in the prospective multicenter trial Kranio...

Objective: Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology is not well known because incidence and prevalence are related to very rare underlying diseases. In addition, different criteria for the syndrome are used across studies. Recognizing HS may be difficult, due to its rareness and variety of symptoms. Having diagnostic criteria for signs and symptoms of hypothalamic dysfunction may aid in early recognition and diagnosis, in the reporting and ...

Craniopharyngiomas (CP) are congenital, benign, embryonic malformations which arise from ectoblastic remnants of Rathke’s pouch and are located in the (supra-)sellar region. Many patients show a reduced growth rate and an increased BMI early before the diagnosis of CP. However, it is unknown whether patients with CP present with increased head circumference before diagnosis. A cohort of 90 patients was screened for medical records of their developmental monitoring visits....

Background: Cardiorespiratory fitness is a measure for physical activity and a prognostic health indicator. However, measurement of maximal oxygen consumption (VO2max) is not possible in clinical practice.Aim: We hypothesized that body composition and testosterone levels could be used as possible determinants of VO2max in young men.Participants and design: The Odense Androgen Study, a population-based, observational study including...

Background: Remote recurrence and metastasis are unusual complications in childhood-onset adamantinomatous craniopharyngioma mainly occurring either along a previous surgical route or by seeding via cerebrospinal fluid.Case description: An 11-year-old female patient initially presented with headache and neck pain as well as nausea over the course of 2 months. A sellar/suprasellar mass (4.0 cm×4.0 cm 5.0 cm) was detected on magnetic resonance imaging...