Endocrine Abstracts

Over the 10 percentage of all intracranial tumors are pituitary tumors.Their malignicity depends on their localisation, meanwhile their biological nature is benign. Regarding the size there are microadenomas (smaller than 10 milimeters) and macroadenomas (10 milimeters or more).Clinical manifestations of pituitary tumors depend on their localisation and hormonal activity. They are either hormonally functional or nonfunctional, resp...

Background: Adjuvant mitotane therapy is frequently used in Europe following surgery for adrenocortical carcinoma (ACC). Management of adjuvant mitotane is mainly empirical and a major open question is the optimal duration of therapy, because no study has ever addressed this issue.Objective: We aimed to assess the outcome of ACC patients who were treated with adjuvant mitotane for at least one year following surgery and then discontinued therapy for othe...

Introduction: Osteoporosis and fractures are common in liver disease and fracture incidence increases after orthotopic liver transplantation (OLT). The value of bone turnover markers (BMTs) in the prediction of bone loss and fracture risk pre- and post-OLT is not known.Study design: The BMTs P1NP, osteocalcin, BALP and CTX were measured initially or in Biobank stored sera at screening and at 3, 6 and 12 months post-OLT in consecutive OLT recipients betwe...

Objective: Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) excess results in both reversible and irreversible damage to the skeleton, and includes increased vertebral fracture (VF) risk in the presence of normal BMD. The prevalence of VFs is approximately 60% in controlled acromegaly patients, and these VFs can progress during short-term follow-up. We aimed to identify the course of VFs and their associated risk factors in a cohort of acromegaly patients in long-t...

Studies that consolidate the results of medicamentous and surgical treatment of pituitary adenomas are scarce. Pure endoscopic endonasal transsphenoidal surgery is rather new technique.The aim of this study is to report on early postoperative outcome of pure endoscopic endonasal transsphenoidal surgery and to present the results of multimodal treatment in patients with postsurgical failure.We reviewed 117 consecutive patients who u...

Introduction: The mammary cancer is the most frequent malign tumor encountered in females, characterized by a high distant metastasis tendency. Among the potential prognosis factors, we mention the biomarkers that measure or are associated with biologic processes involved in the tumorous progression. The study analyzes the p53 protein’s positivity in correlation with the mammary cancer’s classical prognosis factors: the hystologic type, the histopathologic degree, th...

Introduction: Vitamin D is postulated to play a significant role in the immune system modulation and its deficiency has been reported in some autoimmune disorders. Polymorphisms of different vitamin D-related genes, among them vitamin D receptor gene (VDR), could either be a risk factor for autoimmune diseases. Therefore the aim of the study was to assess the association between VDR Cdx2 (rs11568820) polymorphism and autoimmune thyroid disease (AITD) among th...

Objective: Obesity and polycystic ovary syndrome (PCOS) affect endomertial receptivity and may cause implantation failure, defective placentation, and pregnancy loss. Glucagon-like peptide-1 (GLP-1) receptor agonist (RA) improved the endometrial function in animal models, presumably by anti-inflammatory action and reduction of endometrial fibrosis. The impact of GLP-1RA on human endometrioum has not yet been investigated.Aim: We compared endometrial tran...

Metabolic-associated fatty liver disease (MAFLD) is a growing cause of hepatocellular carcinoma (HCC), but the molecular mechanisms associated with the pathological progression from MAFLD to HCC are still to be fully elucidated. The genomic and transcriptomic profile of HCC samples have been widely described; however, the proteomic landscape of MAFLD-derived HCC samples is mostly unknown. Here, we sought to perform the first quantitative proteomic analysis of HCC samples from ...

Metabolic associated fatty liver disease (MAFLD) is rapidly becoming a major aetiology for the development of hepatocellular carcinoma (HCC, the most common liver cancer) in the context of chronic liver disease. Current therapeutical options for MAFLD (dietetic/lifestyle intervention and/or pharmacological approaches) are still insufficient and the cellular and molecular mechanisms underlying this disease are yet to be fully understood. Our group previously reported that the n...