Endocrine Abstracts

Aim: Thyroid hormones act both insulin agonistic and antagonistic in different organs. Studies that evaluate the relationship between insulin resistance and hypo-hyperthyroidism have conflicting results, even euthyroid status was shown to change insulin sensitivity. In this study, our aim is to investigate the association between TSH, free T4, free T3 levels and insulin resistance in euthyroid patients.Method: Euthyroid 57 males, 47...

Introduction: Association between ankle-brachial index (ABI) and coronary, cerebral, and peripheral vessels involvement has been shown in different studies. The normal range of ABI is between 0.9 and 1.4. Values below 0.9 show peripheral vessel disease. An ABI more than 1.4 is characteristic for vascular rigidity. We aimed to investigate the ABI value in our type 2 diabetic patients and association of ABI with glycemic control.Materials and methods: This...

Aim: Diabetes mellitus affects many systems and one of them is skin. Skin findings among diabetic patients reported 30–71%. Skin findings may be due to direct metabolic effects of diabetes but complications and drugs may be cause as well. In this study our aim was to investigate the skin findings and prevalence among diabetic patients that admitted to endocrinology policlinic.Method: 81 patients involved to study, skin examination of the patients we...

Background: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated maternal risk factors and parameters of body composition to develop a prediction model for GDM in early gestation.Methods: A prospective observational study was undertaken. Pregnant women aged between 18–50 y of age with gestational age between 10–16 weeks were included in ...

Background: Globally, birth-weights are increasing progressively. Birth-weights large for gestational age (LGA) defined as ≥90th centile are linked to increased delivery complications, and adiposity in the neonate. This has been linked to glucose intolerance and CVD later in life. Oversupply of nutrients in utero contribute to excess foetal growth, and maternal obesity may contribute to this rise. The aim of this study is to examine the relationship between para...

Background: Adipocytokines are biologically active substances produced by adipocyte with different physiological functions. Adiponectin, an adipocyte derived protein has multiple effects on homeostatic mechanism that regulate body weight and metabolism. Leptin, a signal of satiety to the brain, is considered as a proinflammatory adipocytokine. Thyroid hormones act on several aspects of metabolic and energy homeostasis influencing body weight, thermogenesis, and lipolysis in ad...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. Kickboxing is a novel cause of hypopituiatarism due to sports related traumatic brain injury (TBI) and isolated GHD is the most common problem (1).The present preliminary study was therefore designed to in...

Introduction: Metabolic syndrome (MS) is a clustering of risk factors. Endothelial dysfunction has been reported in patients with MS and even in healthy obese individuals with a normal metabolic profile. Sympathetic activity commonly is increased in obese hypertensives, and moxonidine, is found to be effective in lowering blood pressure and improving insulin sensitivity. The aim of this study is to evaluate the efficacy of moxonidine on endothelial dysfunction in insulin-resis...

A 42 year old gentleman presented for a second opinion regarding management of Congenital Adrenal Hyperplasia (CAH) of the salt losing variety. The patient had been under long term follow up elsewhere but had discontinued his medication of his own accord 14 months prior to seeking consultation. Examination revealed a heavily pigmented male patient with protuberant belly. He had easily palpable masses in both flanks. An abdominal CT showed bilateral massive adrenal enlargement ...

An 18 year old young man was first seen in the ENT department with bilateral swelling of the supraclavicular fossae. A clinical diagnosis of Cushing's syndrome was made and the patient was referred to the Endocrine team. Examination showed a BP of 150/100 and clinical features of gross Cushing's syndrome. Initial investigations revealed normal electrolytes, fT4 8.7 pmol/L, TSH 0.69 mIU/L and a basal prolactin of 68280 mIU/ml. A 24 hr urinary free cortisol (UFC) was 3860 nmol/L...