Endocrine Abstracts

Adult Growth Hormone Deficiency (AGHD) is associated with osteoporosis. PTH circadian rhythmicity is important for bone remodelling. Abnormalities in PTH circadian rhythms, including a blunted nocturnal rise, have been reported in AGHD and may contribute to osteoporosis development. GH replacement (GHR) results in improvement of PTH circadian rhythmicity and bone mineral density (BMD). In health, increasing age is associated with declining GH secretion and the appropriateness ...

Alterations in PTH circadian rhythmicity have previously been reported in Adult Growth Hormone Deficiency (AGHD) and may contribute to the pathogenesis of AGHD-related osteoporosis. However, changes in PTH circadian rhythm have not been correlated with bone mineral density (BMD) in AGHD. Serum phosphate is a likely determinant of PTH rhythm. We examined the PTH and phosphate circadian rhythms in AGHD patients with reduced (defined as femoral neck T-score <-1.0) and normal B...

Growth hormone (GH) and leptin regulate body composition and leptin is elevated in adult growth hormone deficiency (AGHD), a syndrome characterised by increased adiposity. We have previously shown that GH replacement for 1 month reduces 24-h mean leptin concentration independent of changes in fat mass. The long tem effects of GHR on leptin have not been described.24-h mean total leptin concentration was measured using half-hourly blood sampling, to accou...

Background: In the core phase of the PAPE study until 24 weeks we have shown that switching to pasireotide LAR (PAS-LAR) in well-controlled acromegaly patients receiving combination therapy of somatostatin analogues and pegvisomant (PEGV), normalizes IGF1 levels in the majority of patients. PAS-LAR induced a significant PEGV sparing effect, but this was at the expense of a higher incidence of diabetes. This extension study until 48-weeks assesses the efficacy, safety and quali...

Background: Measuring testicular volume (TV) by orchidometer is a standard method of pubertal staging in boys. A paucity of evidence exists as to its inter and intra-user reliability and the impact of clinicians’ gender, training and experience on the accuracy of measurements. Specifically engineered prosthetic models of different size testes were developed to investigate the reliability of TV estimation.Method: The study was conducted over the thre...

Prostate Cancer (PC) affects 1-in-6 men in the UK, and obesity 1-in-3, with rates of both increasing. High-fat diet is linked with increased risk of PC death, and volume of peri-prostatic adipose tissue (PPAT) is associated with increased risk of lethal PC/reduced therapy response. Despite this, molecular mechanisms underpinning obesity-driven PC remain poorly-understood. This is important since weight-gain and central obesity are major side-effects of PC trea...

Background: Adrenal incidentalomas (AIs) detected on pre surgical scans often present a logistical challenge due to the pressing need for preoperative exclusion of a phaeochromocytoma. Our local guideline recommends endocrinology referral for all AIs for further investigations, including pre clinic 24-hr urine metadrenalines. This approach can be time-consuming, particularly for patients awaiting unrelated surgery.Methods:</stron...

Background: Primary hyperparathyroidism may severely manifest with an adjusted calcium >3.5mmol/l and increased risk of prolonged postoperative hypocalcaemia. Formal consensus on preoperative optimisation appears lacking, especially around the utility of parenteral bisphosphonate treatment. Bisphosphonate therapy has been demonstrated to cause prolonged hypocalcaemia when given to patients with a history of parathyroidectomy....

Background: Predictions estimate that the majority of the global population will be living with overweight and obesity by 2035. Due to its widespread use and ability to disseminate information, social media has a potentially prominent role in obesity care and education. Regulatory bodies issue ethical guidance on social media use. However, it is unknown how healthcare professionals’ (HCP) online activity affects people living with obesity. By exploring th...

Background: Testosterone therapy is recommended for the management of puberty in Duchenne muscular dystrophy (DMD) from 12 years, according to the 2018 international standards of care with studies demonstrating improvement in linear growth. The majority become non-ambulant during mid-to-late adolescence. Accurately measuring height in non-ambulant adolescent boys can be challenging compounded by lower limb contractures. Estimated height from segmental body par...