Endocrine Abstracts

BackgroundAlthough patients with diabetes mellitus (DM) are at higher risk of hip fracture, data regarding the effect of DM on rehabilitation outcomes is limited.MethodsA retrospective population-based study was conducted comparing diabetic and non-diabetic elderly patients with a recent hip fracture who were admitted to a geriatric rehabilitation facility during 2014–2019. The Functional Independence Me...

Hyperprolactinaemia is a common referral reason from primary and secondary care for contrast-enhanced pituitary magnetic resonance imaging (MRI). This retrospective study at University Hospitals of North Midlands, Stoke-on-Trent reviewed the records of new patients referred for pituitary MRI between 1 June 2021 and 31 May 2023 with hyperprolactinaemia as indication. 71 patients were identified. 82% of the cohort were women. Age ranged between 18-87 years; the majority were bet...

Background: Despite the widespread use of immunohistochemistry (IHC), there are debates on how pre-analytic variables influence diagnostic results, including the effect of varying tissue section thickness. Scant literature suggests that tissue thickness can affect stain interpretation, including nuclear stains that rely on assigning tumor cells to the positive category, such as Ki-67, and raise the question of whether tissue section thickness should be standardized for some di...

Somatostatin is a hormone and neuropeptide expressed in the pancreas, gastrointestinal tract, hypothalamus, and other tissues. It regulates directly the secretion of insulin, glucagon, many of the gastrointestinal hormones, and growth hormone. It is therefore surprising the somatostatin knockout (sst-ko) mice have a very mild phenotype. We subjected sst-ko mice and heterozygous siblings which served as controls to a high-calorie diet, and confirmed that sst-ko mice gain weight...

Background: Diabetes Mellitus (DM) is increasing in prevalence worldwide. Sex differences in glycaemia attainment may be relevant in the management of type 2 DM.This study determined gender differences in glycaemic targets in patients with type 2 diabetes attending the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile- Ife.Method: This cross-sectional descriptive study involved fou...

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

Background: A case report of Nigeria male who presented on account of bilateral gynaecomastia and was found to be azoospermic on investigation with a view to draw attention of clinicians to underling endocrine problems associated with gynaecomasia.Methodology: A case report of a 32 year old Nigeria man with progressive-bilateral breast enlargement was reviewed.Case report: A 32 year old Nigeri...

Background: Diabetes Mellitus (DM) is increasing in prevalence worldwide. Sex differences in glycaemia attainment may be relevant in the management of type 2 DM.This study determined gender differences in glycaemic targets in patients with type 2 diabetes attending the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile- Ife.Method: This cross-sectional descriptive study involved fou...

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

Background: A case report of Nigeria male who presented on account of bilateral gynaecomastia and was found to be azoospermic on investigation with a view to draw attention of clinicians to underling endocrine problems associated with gynaecomasia.Methodology: A case report of a 32 year old Nigeria man with progressive-bilateral breast enlargement was reviewed.Case report: A 32 year old Nigeri...