Endocrine Abstracts

Aim: Thyroid surgery in children is infrequently undertaken, but due to genetic screening of families with multiple endocrine neoplasia (MEN) syndromes, more paediatric thyroidectomies are being performed. In this study we explored the indications for thyroidectomy and the post operative course and consequences of surgery carried out in our unit.Methods: Retrospective review of medical case notes of children who had either total or partial thyroidectomie...

Objectives: It is well known that compounds of follicular fluid, which is rich in carbohydrates, are able to regulate the expression of angiogenesis-related genes in endothelial cells. Nuclear factor κ B (NF-κB) transcription factors are important candidates in modulating the expression of these genes. The aim of our research is to determine if NF-κB factors are maybe involved in the regulation of endothelial angiogenesis-related genes and thus in ovarian angiog...

A 60 year old pest control worker presented to the dermatologists with a 3-month history of progressive thickening and change in texture of skin lesions affecting the face, lips and eyelids. Histology revealed papular mucinosis/lichen myxoedematosus and he was treated with plasma exchange, high dose steroids and cyclophosphamide. Investigations for associated tiredness, four months following presentation and initiation of therapy revealed impaired GH and cortisol responses to ...

Introduction: haemangiopericytoma is a rare soft tissue tumour originating from pericytes and manifest rarely as hypoglycaemia that can be difficult to treat. We report a case of haemangiopericytoma induced hypoglycaemia treated successfully with radiotherapy.Case report: A 72-year-old lady presented with an episode of confusion. She had had similar episodes usually in the early morning hours. She had had a large bladder haemangiopericytoma removed surgi...

The Wnt developmental pathway has been implicated in tumour growth and development in a number of tissues. Most frequently, the canonical Wnt pathway acting through the nuclear translocation of B-catenin has been the key player in driving tumour growth. However, non-canonical Wnt pathways, namely the Wnt-Calcium signalling and the Wnt-planar polarity pathways have also been found de-regulated in a number of cancers. In this study, microarray analysis on locally resected PA rev...

Sarcoidosis is a very rare inflammatory disease and UK prevalence was 8% between 2008 to 2012 of which only 15 % developed neurosarcoidosis. Our patient is a 83 year old gentleman who presented with symptoms of lethargy, low blood pressure and confusion over 2 weeks . He had multiple comorbidities including heart failure, chronic kidney disease, permanent pacemaker, hypertension. His bloods showed normocytic anaemia and raised inflammatory markers, with eosinophilia and he was...

Introduction: Hyponatremia (HN) is the most common electrolyte disorder of hospitalized patients (pts). It occurs in up to 28% of in-pts, increases the in hospital risk of death by 1.47 fold, and is associated with significantly higher mortality risk following discharge. The HN Registry is the first large scale, international effort to document the clinical characteristics, treatments used, and impact of HN in hospital settings.Methods: After informed co...

Introduction: The reason for weight gain is multifactorial. Effective intervention can only be incorporated if the underlying cause is evaluated correctly. Here we present a lady with Addison’s disease who gain significant weight and was helped to lose weight using a novel approach.Case-Report: 42 year-old lady was referred to our weight-management service as she was unsuccessful in losing weight. Detailed evaluation in the obesity clinic revealed t...

Background: Variable rate intravenous insulin infusion (VRIII) or ‘sliding scale’ is required for certain patients with diabetes to keep their blood glucose within the recommended target range during an acute illness or a period of starvation. When used in the right context this has shown to improve outcomes but can also lead to morbidity especially hypoglycaemia.Aim: Evaluate risk of hypoglycaemia in patients on VRIII with concurrent use of ba...

Background: Relacorilant is a highly selective glucocorticoid receptor (GR) modulator in development for the treatment of endogenous Cushing syndrome (CS). Unlike the GR antagonist mifepristone, relacorilant lacks affinity for the progesterone and other receptors. In a phase 2 study in patients with CS (Pivonello et al, 2021), relacorilant provided clinically meaningful changes in several cortisol-excess-related comorbidities, including hypertension and hyperglycemia,...