Endocrine Abstracts

Background: Glucocorticoid (GC) therapy is the standard management for Duchenne Muscular Dystrophy (DMD), but its use is associated with significant side effects, including weight gain. Limited research exists on the impact of GC initiation on body composition in DMD, particularly regarding the timing of fat mass increase.Objective: This study aimed to assess changes in growth parameters, namely height-SDS, weight-SDS, b...

Background: Lu177 DOTATATE Peptide Receptor Radionucleotide Therapy (PRRT) was FDA approved in the United States in 2018, however, the data for the safety and efficacy of repeat PRRT are almost exclusively from European centers. We present an updated experience with repeat PRRT in a cohort of US patients.Methods: We used our single-center longitudinal IRB approved neuroendocrine tumor (NET) registry to identify patients who had been previously treated wi...

Background: Clinicians are concerned about increased hepatotoxicity in patients who received hepatic artery bland embolizations (TAE) and subsequent Peptide Receptor Radionuclide Therapy (PRRT). The body of literature describing the safety of PRRT following prior TAE is very limited. The purpose of this study is to evaluate the degree of long-term liver toxicity in patients who received PRRT in addition to previous hepatic embolizations for liver dominant disease.<p class=...

Background: Pancreatic neuroendocrine neoplasms (panNENs) are heterogeneous, with grade (G) defined by Ki67 proliferation index (<3% G1, 3-20% G2, >20% G3) or mitotic rate. The G3 NEN subgroup is further divided into well differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NEC). Grade progression can occur over time, with low-to-high grade progression (L-to-H; G1/2 to G3) the most clinically relevant form. It is associated w...

Background: Neuroendocrine tumors (NETs) are classified as functional or non-functional based on the presence of characteristic symptoms, related to tumoral secretion of biologically active peptides or amines. Carcinoid Syndrome (CS) is the commonest functional NET syndrome, seen at diagnosis in 19% of patients. It is characterized in over 80% of cases by watery diarrhea (mainly due to serotonin hypersecretion) or cutaneous flushing. Somatostatin is a neuropeptide that inhibit...

Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 1...

Rathke’s cleft cysts (RCC) arise from the embryonic remnants of Rathke’s pouch in the anterior pituitary gland. The majority are asymptomatic and incidentally diagnosed when the pituitary is imaged for other reasons. RCCs can progress to requiring surgical intervention for hormonal and structural effects. It is unclear what factors determine RCC enlargement and over what period this occurs, hence need for long term follow-up is uncertain. We analysed our conservative...

A 57-year-old woman with poorly controlled type 2 diabetes (HbA1c 148 mmol/mol) presented acutely with lower back pain, in the absence of trauma. Her WHO performance status score was 2. 18 months earlier she had developed a left fifth toe ulcer, resulting in left forefoot amputation six months later which had not healed. She had also developed a neuropathic ulcer in her right hallux, complicated by osteomyelitis. Despite excellent peripheral vasculature, conservative therapy w...

Introduction: Hyponatremia is the most common electrolyte disorder in clinical practice, and evidence to date indicates that severe hyponatremia is associated with increased morbidity and mortality. The aim of our study was to perform a comprehensive meta-analysis that included all the published studies that compared mortality rates in subjects with or without hyponatremia of any degree.Methods: An extensive Medline, Embase, and Cochrane search was perfo...

Background: Adult growth hormone deficient (AGHD) is associated with reduced bone turnover and reduced bone mineral density (BMD): factors improved by growth hormone replacement (GHR). Obesity is associated with reduced bone turnover but increased BMD. We investigated the impact of body mass index on parathyroid hormone (PTH), phospho-calcium metabolism and bone turnover in AGHD patients before and after GHR.Study design: Of 31 AGHD patients (15 obese pa...