Endocrine Abstracts

Introduction: Acromegaly is associated with many different types of benign and malign neoplasm, putatively because of the chronic elevation of IGF-1. Colorectal, thyroid and breast neoplasms are well-established associations; there are many other possible ones, such as prostatic and uterine neoplasms, meningioma, leukemia, lymphoma, renal, pulmonary, esophageal and gastric tumors. Also in the context of MEN-1, parathyroid and pancreatic neoplasms are associated with acromegaly...

Objective: Functional hypercortisolism associated with alcohol abuse is an infrequently diagnosed entity of unknown prevalence. Ethanol elicits hypothalamic oversecretion of CRH with subsequent increase in ACTH and cortisol. It may simulate Cushing’s disease both clinically and biochemically but there are no anatomic lesions and the diagnosis is confirmed by normalization of the biochemical pattern after at least 1 month of abstinence from alcohol. We hereby report a clin...

Introduction: Empagliflozin has a well-established anti-albuminuric effect in patients with T2DM, but in almost all available trials the baseline blood pressure was well controlled with SB P<140 mmHg. We analyzed the impact of empagliflozin treatment in patients with T2DM and uncontrolled hypertension, and its relationship with the changes in HbA1c and SBP.Methods: Retrospective analysis of the albuminuria, SBP and HbA1c data in patients wit...

Introduction: It has been reported that patients with obesity and T2DM treated with oral semaglutide not only have a reduced total caloric input, but they also tend to reduce the proportion of fatty and sweet foodstuffs in an ad libitum diet. A modest improvement in the lipid profile of patients with obesity and T2DM treated with oral semaglutide has been reported, but its dependence on weight loss is not well established. We undertook to study the mediation effect of...

Introduction: We have recently reported that the use of cyproterone acetate (CPA) is associated with a highly significant increase of the risk of hypertension development after 5 years (adjusted hazard ratio 0.227, P< 0.001) in young transgender women. Due to the risks associated with the prolonged use of CPA (including the development of meningioma), the EMA presently recommends avoiding the use of doses > 10 mg CPA daily if possible. In fact, acceptable effi...

Introduction: Extended-release (ER) metformin has been available in many countries for the last two decades, and it may have definite advantages vs. conventional (i.e., immediate-release) metformin: Reportedly, it may reduce gastrointestinal adverse effects by about half, thus increasing compliance; moreover, the once-a-day schedule may contribute to increased adherence and persistence, and hopefully improved outcomes. However, ER metformin was unavailable in Spain until 2022:...

Introduction: Although usually considered as benign tumors, cavernous hemangiomas are venous malformations due to endothelial dysmorphogenesis and not true neoplasias. They are usually asymptomatic but occasionally can cause compressive symptoms or serious internal bleeding. They may arise in almost any vascularised organ, but their presentation in an adrenal gland is highly infrequent, and can masquerade as pheochromocytoma, adrenal carcinoma or metastatic malignant lesion.</...

Introduction: Dulaglutide (Trulicity®) is a long-acting GLP-1 agonist that received US Food and Drug Administration (FDA) approval in 2014. Dulaglutide is a large sized molecule, which limits its renal clearance. This allows for once weekly dosing; which might improve patient compliance significantly. Extensive Phase III study data have been published with regard to dulaglutide, much of which was part of the AWARD studies, which provide evidence for its use in ...

Diabetes and acute hyperglycemia are known to increase stroke volume and disability in stroke patients, and deliver worse outcomes after reperfusion therapies. Chronic glycemic status has recently been linked to stroke functional outcome, but its impact on long term prognosis of stroke has rarely been studied. We conducted a study to investigate the impact of glycosylated hemoglobin (HbA1c) levels on functional outcome 1 year after stroke.Methods: Patien...

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Due to a increased use of improved radiological techniques, especially ultrasound. This study aims to analyze histological characteristics of DTC diagnosed in our hospital in the last fifteen years.Patients and methods: It is a restrospective descriptive study. We have included all operated patients in our center between 2001 and 2015 with a final b...