Endocrine Abstracts

Introduction: Langerhan Cells Histiocytosis (LCH) is a rare heterogeneous idiopathic clinical entity involving clonal proliferation of Langerhan cells that may infiltrate most commonly bone, skin, lymph nodes or lungs. It affects mainly children between 5 and 15 years. The most common endocrine manifestation is diabetes insipida.Clinical case: The authors describe a case of a 19-year-old female patient, admitted in the Transition Follow-up of the Endocri...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) in patients with congenital heart disease (CHD) has an estimated cumulative incidence of 13–21%, and prompt reversal to euthyroidism is crucial in these patients. We present a case of refractory AIT in a patient with CHD who was treated with thyroid arterial embolization (TAE).Clinical case: A 34-year-old male with complex cyanotic CHD (great vessels transposition, interventricular communication...

Introduction: Malignant toxic thyroid nodules are rare, with few cases described in the literature. The prevalence of malignancy in toxic adenomas varies between 1 and 8% in different series (most, corresponding to <2.5%). For that reason, international guidelines recommend that they should not be submitted to fine needle aspiration biopsy.Case report: A 42-year-old female patient without relevant previous medical history was admitted to our hospital...

Introduction: Thyroid nodules in children and adolescents are less prevalent, but entail greater risk of malignancy than in adults. Most are asymptomatic because they are associated with normal thyroid function, but their prevalence is increasing due to the incidental diagnosis by neck ultrasound.Aims: To evaluate the characteristics of a pediatric population with thyroid nodules submitted to fine-needle aspiration (FNA) biopsy.Met...

Introduction: McArdle disease is a rare recessive disorder of glycogen metabolism, related to muscle phosphorylase deficiency. It usually presents in adolescence or early adulthood with muscle cramps, exercise intolerance, easy fatigability, and progressive weakness as glycogen is the primary source of energy for intense muscle activity. Few reports described the association of McArdle disease and type 2 diabetes and some authors suggested that hyperglicemia and hyperinsulinem...

Introduction: About 20% of fine needle aspiration biopsy of thyroid (FNA) with result of follicular tumour (FT) is malignant. Several factors have been suggested as indicators of malignancy.Objectives: To determine predictive factors of malignancy in FNA with result of FT.Methods: We evaluated retrospectively 140 clinical files of patients with cytology (ultrasound-guided or palpation) of FT. Presence of relationship between malign...

Differentiated carcinoma of the thyroid (DCT) of follicular origin is the most frequent endocrine neoplasia and it usually has a good prognosis even in the disseminated disease, due to its slow growing pattern and low dissemination rate. The prevalence of metastasis described in the literature varies between 5 and more than 20%.Aims: To analyze the clinical–pathological data and their relation with survival of patients (pts) with metastatic DTC....

Aims: End stage renal disease is associated with disorders of calcium and phosphate metabolism that favor the loss of bone mass.Kidney transplant may alter this unbalance restoring bone mass. Nevertheless, recent studies showed that 48 months after transplant, the loss of bone mass still is superior to general population. Post-transplant corticosteroid therapy is considered the main responsible for the loss of bone mass.The authors...

Craniofacial proportions of girls with TS, compared to normal children, show reduced size of the craniofacial complex, retrognathic profile and tendency towards advanced dental age. Growth hormone (GH) treatment in TS positively affects stature, but its effects on craniofacial growth and dental development are largely unknown. The aim of this study was to analyze and to correlate the craniofacial morphology, chronological, dental and bone ages of TS patients receiving GH or no...

Growth is a complex process, influenced to a large extent by GH. Children with GH deficiency (GHD) have typical somatic features, including short stature and a reduction of the craniofacial structures. Dental age (DA) is normally delayed in relation to chronological age (CA). The effect of GH replacement on craniofacial growth is still poorly understood. We studied the craniofacial development and dental maturation in 17 patients (4F, 13M) with GHD of different etiologies. The...