Endocrine Abstracts

Differentiated Thyroid Cancer (DTC) is the most common malignant tumor in endocrinology, being the papillary subtype frequently found. The DTC is usually indolent and with a more favorable clinical prognosis of survival in 10 years, which has been diagnosed more frequently after the development and dissemination of complementary detection methods, according to the world literature. However, access to imaging exams with increasing resolving power makes a large number of low-ris...

Perinatal maternal high-fat (HF) and isocaloric diet induced obesity and metabolic disorders in the offspring since weaning. At adulthood, oxidative soleus skeletal muscle of HF male offspring exhibited lipid accumulation and mitochondrial damage. At birth, HF offspring have higher n-6:n-3 polyunsaturated fatty acids (PUFA) plasma ratio. We hypothesized that HF offspring´s mitochondria of skeletal muscle exhibit damages at weaning that could be mitigated by fish oil (FO, ...

Introduction: The prevalence of palpable thyroid nodules in Graves’ disease (GD) is approximately 15%. Cytopathologic interpretation in GD is challenging due to frequent cytomorphologic changes, namely after radioactive iodine (RAI) therapy. Some of the few published studies regarding fine-needle aspiration (FNA) in patients with GD, suggest an increased risk of malignancy of thyroid nodules arising in GD patients. However, the results are inconsistent, and there is no co...

Introduction: Breast cancer is the second most common neoplasm in women. Hormonal replacement therapy and combined hormonal contraception are established extrinsic hormonal risk factors for breast cancer. Therefore, the increase in the prevalence of infertility and the use of assisted conception techniques have raised questions regarding the potential risk of hormone-dependent neoplasms. We report the case of a woman diagnosed with bilateral metastasized breast cancer soon aft...

Insulinoma, a rare neuroendocrine tumor (NET), is benign in more than 90% of cases. We present a review of patients diagnosed with insulinoma at our Department.Methods: Retrospective review of clinical records of patients diagnosed with insulinoma between 2011 and 2016.Results: Six female patients were diagnosed with insulinoma (age at presentation 30–66, follow-up: 0.25–3.25 years). Episodes of sweating, palpitations, tr...

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, wit...

Background: In the recent years, Vitamin D role has grown in cardiovascular and inflammatory diseases, and some relations were made with low serum testosterone (LST) levels. It is equally known that in patients with diabetes, the prevalence of LST is higher.Objetive: To determine the prevalence of low levels of vitamin D and its relation with LST in men with diabetes.Material and methods: A cross-sectional study of 65 men with type...

Background: Pituitary adenomas (PA) are common intracranial tumors that are mainly considered benign. A small group of patients exhibit clinically aggressive behavior sometimes unrelated to the histopathological or radiological features.Methods: Twelve patients were selected harboring a PA with clinical features of aggressiveness. All the patients underwent pre and postoperative endocrinologic/neuroradiologic evaluation.Results: 10...

Introduction: During childhood and puberty, growth hormone(GH) is essential for linear growth. Consequently, children with isolated GH deficiency(GHD) must receive replacement therapy. GH has also important metabolic actions. GHD in adults is associated with altered body composition. However, long-term consequences of GH treatment in adults is not sufficiently known.Objective: To evaluate GH treatment during pediatric age in patients with isolated GHD.</...