Endocrine Abstracts

Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed accordin...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome. In this study, we evaluated the degree of metabolic disorders in women with different PCOS phenotypes.Methods: We analyzed 162 women with PCOS (BMI: 24.9±6.1 kg/m2, age:25.6±5.6 years) diagnosed on the basis of ESHRE/ASRM criteria, and 39 women without PCOS who comprised the control group (CG; BMI: 21.4±4.1 kg/m...

Introduction: Polycystic ovary syndrome (PCOS) is associated with higher risk of cardiovascular disease. Measurement of carotid intima-media thickness (CIMT) is a simple non-invasive procedure for assessment and measurement of atherosclerotic plaque. It is a valuable tool for evaluation of cardiovascular disease risk, as increase in CIMT is associated with cardiovascular events, mainly stroke. In this study we evaluated association and influence of metabolic disturbances on CI...

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

Introduction: Pancreatic neuroendocrine tumors (PNETs) are generally clinically more indolent than adenocarcinomas. But relevant, clinically applicable prognostic survival factors still need to be more precisely defined.Aim: To identify survival factors in patients with PNETs.Methods: We analyzed 66 patients with PNETs (52.62±13.3 years old) treated at our department during 2003–2010. Patients with insulinomas were not in...

Introduction: Several studies have shown that cortisol and altered HPA axis activity may participate in pathogenesis and severity of coronary artery disease (CAD).Aim: To examine possible interaction between cortisol secretion and HPA axis activity with severity of CAD.Patients and methods: Diurnal cortisol secretion and dexamethasone suppression test (DST) were analyzed in 200 consecutive patients (mean age 59.3±8.6) referred...

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...