Endocrine Abstracts

Introduction: Central diabetes insipidus is characterized by partial or total ADH deficit of various origins. The clinical picture is dominated by massive polyuria with diluted urine, increased thirst and daily water consumption reaching impressive quantities. Case report: We report the case of a 16 year-old male teenager presenting with excessive thirst and water intake of 8 -10 l/day and voiding large quantities of diluted urine. Symptoms started gradu...

Introduction: Fear of illness and quality of life have been proven to be affected in women with osteoporosis. Osteoporosis causes an increase in morbidity and mortality but the direct ways by which it affects fear of illness and quality of life are not yet known. The present study aims to assess the fear of illness and quality of life (QoL) as well as their correlation with bone density and age in a Greek rural population of postmenopausal women with osteoporosis.<p class=...

Introduction: Traumatic brain injury (TBI) is the leading cause of death and disability in young adults. It is important to recognise pituitary dysfunction following TBI as it can cause significant morbidity.Methods: 179 TBI patients (137 males) age 41.0±15.7 years (17.6–88.1 years) attended Charing Cross Hospital clinic (July 2009–August 2011). Median time since TBI was 0.27years (0.05–46.5 years, 26% >1 years). 34% had an intrac...

Aberrant adrenal LH expression is a rare cause of adrenal Cushing’s syndrome (CS) leading to transient hypercortisolism during pregnancies and ACTH-independent macronodular adrenal hyperplasia (AIMAH) after the sustained postmenopausal increase of LH secretion. Subclinical CS due to aberrant LH expression has very rarely been described. Herein, we report a case with aberrant LH/hCG adrenal receptor mediated subclinical CS in a patient with incidentally discovered AIMAH an...

Several studies have shown a positive correlation between parity and reduced hip fracture rate later in menopause while others have shown no correlation or a negative one. Thus, it is possible that some of the conflicting results reported in literature may be attributable to differences in the ages of the populations studied or of the concomitant presence or not of osteoporosis.In order to elucidate these conflicting results, a population based observati...

Introduction: Adiponectin is secreted by adipocytes and has been linked to glucose and lipid regulation. Obesity, diabetes and atherosclerosis have been associated with reduced adiponectin levels. Orlistat lowers lipids and improves insulin sensitivity but its effect on other metabolic parameters is not known.The purpose of this study is to evaluate the influence of orlistat on metabolic and hormonal parameters of the adipose tissue.<p class="abstext...

Introduction: Resistin is a peptide hormone that is secreted from fat cells and its secretion is regulated from hormonal and dietary factors. In hypothyroid patients its levels are decreased.The purpose of this study is to evaluate the levels of circulating resistin in hypothyroid patients before and after thyroid function is normalized with thyroxin therapy.Materials and methods: Twenty (20) hypothyroid patients (2M, 18F) mean age...

An association between testicular function and vasoconstrictive peptide endothelin-1 levels, which is produced by Leydig and Sertoli cells, is observed. Endothelin –1 regulates blood flow in the testis and stimulates testosterone secretion.The purpose of this study is (1) to estimate the influence of tamoxifene and raloxifene therapy on enthothelin-1 levels in men of reproductive age with idiopathic hypogonadism. (2) To find an association between i...

The mammalian target of rapamycin (mTOR) is a serine kinase that couples energy and nutrient abundance to cell growth and is critically involved in the onset and progression of diabetes, cancer and ageing. Placental mTOR is involved in nutrient sensing and transfer to the fetus. Animal models suggest that placental mTOR is upregulated in pregnancies complicated by gestational diabetes (GDM). Our aim was to characterize expression, and cellular localization of mTOR and whether ...

IntroductionAlthough addressability for breast pathology is much lower in men than in women, the underlying causes of the initial complaints are often much more spectacular. Gynecomastia is one of the principal reasons for addressing the endocrinologist and next to the important psychosocial impact, sometimes it seems to be only the tip of the iceberg, revealing important underlying medical conditions.Case reports<p class="abst...