Endocrine Abstracts

Introduction: Quality of life (QoL) is a subject of increasing interest in the health context. Applied to a chronic condition like diabetes, this issue could give an overall perspective of the health outcome.Objective: To evaluate the coping mechanisms, the treatment issues and its contribution to QoL of diabetes patients.Patients and methods: We gathered a sample of 94 diabetic subjects, 50% males, 55.3% type 1, with a mean age of...

Introduction: Obesity is nowadays one of the most important challenges in public health and, therefore, the investigation of their causes is most relevant. Among the various behavioral roots of obesity, the emotional over ingestion determined by emotional factors, i.e. emotional eating (EE), is one of them.Objectives: To study how emotions contribute to obesity in woman.Methods: We gathered a convenience sample 220 woman in the hos...

Case history: A 74-year old gentleman was referred from Urology clinic for hypercalcemia after being treated for left vesico-ureteric calculus causing mild hydronephrosis. Past medical history included asthma, eczema and hypertension. He had been taking calcium supplements for 5 years, but stopped 2 months prior to clinic. He was asymptomatic and quite well with no recent fracture.Investigations: Adjusted Ca ranged from 2.62 to 2.78 mmol/l, PTH from 2.6 ...

Background: Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma, but it rarely presents as an intrathoracic mass with concurrent hyperthyroidism due to Graves disease.Case presentation: A 73-year-old man presented with weight loss. Imaging by computed tomography (CT) documented a large mediastinal mass in the infrathyroidal space separate from the thyroid gland and pulmonary lesions suggestive of metastases. Neck ultrasound showed...

Introduction: Radioactive iodine (RAI) is an effective and widely used treatment for thyrotoxicosis. Post-radioiodine thyrotoxicosis is a well-known side effect of RAI. This is usually mild and easily controlled mostly with beta blockers but sometimes needs anti-thyroid drugs (ATD).Aim of the study: To assess the incidence and predictors of post-radioiodine thyrotoxicosis.Methods: Retrospective analysis of 86 patients who had RAI t...

Aim: Radioiodine activities for the treatment of Graves’ disease hyperthyroidism are still subject to discussion, as is the use of a fixed approach over a dosimetric one. We aimed to evaluate our success rate using a personalized dosimetric approach: instead of the “(MBq I-131×g gland mass×100)/(percentage uptake at 24 h)” activity calculation, we further adjusted for factors such as gender, age, diagnosis, 2 h and 4 h radioiodine uptake, previous medi...

Objective: To analyze the clinicopathological features of pseudohypoparathyroidism (PHP), that would help clinicians to consider this rare condition in children.Methods: A retrospective review of nine patients with PHP (including seven males and three females) admitted to our hospital between 1990 and 2014 was conducted. Clinical and biochemical parameters along with epidemiological data were extracted and analyzed.Results: The mea...

Introduction: Immune checkpoint inhibitors (ICPIs) are recent approved drugs used in malignant melanoma, non-small-cell lung cancer and renal cell cancer. They act by activating host T cell against malignant antigens. Immune checkpoint blockade can lead to breaking of immune self-tolerance, thereby inducing autoimmune/autoinflammatory side effects, such as endocrinopathies. It may affect thyroid, adrenal and pituitary. We present two ICPIs induced thyroiditis cases.<p clas...

Context: Lipodystrophy is characterized by subcutaneous fat loss, fat maldistribution, and metabolic syndrome. We present a novel phenotype of partial acquired lipodystrophy, possibly associated with childhood chemotherapy.Case reports: Two adult female patients that had been exposed to intensive cytostatic treatment in childhood for leukemia and aplastic anemia, respectively, were referred for therapy resistant diabetes. Both patients had distinct parti...

A 48 year-old lady was referred to Endocrinology clinic in November 2016 with symptoms of tiredness and lethargy for two months. Routine bloods were unremarkable, apart from an incidental finding of raised Vitamin D:258 nmol/l(NR: 50–150). She had depression and was otherwise fit & well. She was on Citalopram and combined oral contraceptive pill (Microgynon). She denied any excessive sun exposure. She didn’t drink any milk, only drank orange juice. She took multi...