Endocrine Abstracts

Pituitary adenomas are present in ∼25% of autopsy samples, and recent studies have also suggested that clinically important pituitary adenomas are some 5 times more common than previously recognised. Acromegaly is almost always due to a sporadic growth-hormone secreting pituitary adenoma, but familial acromegaly has been reported occasionally. Linkage and loss of heterozygosity studies have shown that it is caused by a tumour suppressor gene located at 11q13; very recent...

Ghrelin is a potent growth hormone (GH) secretagogue in rats and in humans. Since stomach is the main source of circulating ghrelin, gastrectomy reduces plasma ghrelin concentrations by 65%. The implications of decreased circulating ghrelin on GH secretion have not yet been investigated. Furthermore, the neuroendocrine pathways through which ghrelin acts to release GH are largely unknown. We aimed to investigate GH response after insulin induced hypoglycemia (ITT) and after sy...

Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 ...

Introduction: CAH is among the most common inherited metabolic disturbances, caused by Ar mutations of genes that encode enzymes involved in the adrenal steroids synthesis. Male hypogonadism and CKD can complicate the course of CAH. Additionally, HD can influence the CAH management by unpredictable effects of ultrafiltration on the levels of administered drugs. The aim of our study is to demonstrate the influence of HD on LH/T levels of eugonadal male as well hypogonadal male ...

Interindividual variations in tissue sensitivity to glucocorticoids have been partly attributed to polymorphisms in the glucocorticoid receptor (GR) gene. The aim of this study was to investigate the prevalence of subclinical hypercortisolism (SH) in women with adrenal incidentaloma (AI), and whether BclI variant of the GR gene may contribute to metabolic abnormalities frequently present in these patients. We evaluated 106 women with AI. Anthropometric characteristics...

Pheochromocytomas and sympathetic paragangliomas are rare catecholamine-secreting tumors and represent very rare causes of intracerebral hemorrhage in young. Few cases of these neuroendocrine tumors which presented with intracerebral hemorrhage have been reported. A 32-year-old man presented to our emergency department because of sudden onset of severe headache. He has a six months history of headache, palpitations and sweating. During examination he became somnolent and devel...

Germline ARMC5 mutations have been described as the most frequent genetic abnormality found in patients diagnosed with primary bilateral macronodular adrenal hyperplasia (PBMAH). PBMAH is a rare etiology of Cushing’s syndrome. This gene has been proposed to acts as a tumor-suppressor gene. A 36-years old female presented to us with clinical signs of hypercortisolism. ACTH dependent Cushing’s syndrome was confirmed soon after. Pituitary magnetic resonance imaging (MRI...

Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9&#17...

Introduction: Hyperandrogenism (HA) is frequent but not universal characteristic in women with polycistic ovary syndrome (PCOS). According to the ESHRE/ASRM definition, hyperandrogenism criterion could be clinical (hirsutism) and/or biochemical (hiperandrogenemia). The aim of this study was to analyze metabolic and hormonal characteristics among women with PCOS with different forms of hyperandrogenism.Methods: We analyzed 458 women with PCOS diagnosed us...

Introduction: Women with polycystic ovary syndrome (PCOS) often have other comorbidities and one of them is Hashimoto thyroiditis (HT). The aim of the sudy was to analyze metabolic and hormonal status among women with PCOS, with and without HT.Methods: We analyzed 167 women with PCOS diagnosed using ESHRE/ASRM criteria divided on PCOS with HT (PCOSwithHT, N=27, age: 25.8±5.2 years, BMI: 28.5±7.3 kg/m2) and without...