Endocrine Abstracts

Introduction: The coexistence of adrenal tumors (AT) in patients with neuroendocrine tumors (NETs) has not been extensively studied. The aim of our study was to investigate their prevalence and clinical significance in these patients.Materials and methods: We retrospectively studied 447 patients with NETs of all localizations, treated at our department between 2004 and 2012. Diagnosis was established pathohistologically, classification performed accordin...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...

Introduction: Women with polycystic ovary syndrome (PCOS) are characterized with insulin resistance and hyperinsulinaemia. Adiponectin and leptin are adipose tissue-specific products and are correlated with insulin resistance. The aim of the study was to access the relation of adiponectin with anthropometric, metabolic and hormonal parameters in a group of women with PCOS.Methods: We studied 57 non-obese women with PCOS diagnosed using ESHRE/ASRM criteri...

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

Background: Phthalates presents widespread endocrine disrupting chemicals in many personal-care and consumer products. A limited number of experimental and human studies suggest that exposure to phthalate may be associated with altered thyroid function, but a problem is not elucidated enough. This study focused to examination of the association between urine phthalate metabolites and thyroid function.Methods: We included 91 healthy person, 47 females and...

Background: Hypothyrosis is an atherosclerosis-promoted condition. On the other hand, nitric oxide (NO) has antiatherogenic cardioprotective properties. By some Doppler ultrasound parameters (intima-media complex thickness (IMCT) and systolic velocity (SV)), one can point out the level of atherosclerosis presence in cardiovascular system out of histopathology.We primarily determine NO levels in studied population and then examine their influence on menti...

Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome. In this study, we evaluated the degree of metabolic disorders in women with different PCOS phenotypes.Methods: We analyzed 162 women with PCOS (BMI: 24.9±6.1 kg/m2, age:25.6±5.6 years) diagnosed on the basis of ESHRE/ASRM criteria, and 39 women without PCOS who comprised the control group (CG; BMI: 21.4±4.1 kg/m...

Introduction: Polycystic ovary syndrome (PCOS) is associated with higher risk of cardiovascular disease. Measurement of carotid intima-media thickness (CIMT) is a simple non-invasive procedure for assessment and measurement of atherosclerotic plaque. It is a valuable tool for evaluation of cardiovascular disease risk, as increase in CIMT is associated with cardiovascular events, mainly stroke. In this study we evaluated association and influence of metabolic disturbances on CI...

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

Introduction: Pancreatic neuroendocrine tumors (PNETs) are generally clinically more indolent than adenocarcinomas. But relevant, clinically applicable prognostic survival factors still need to be more precisely defined.Aim: To identify survival factors in patients with PNETs.Methods: We analyzed 66 patients with PNETs (52.62±13.3 years old) treated at our department during 2003–2010. Patients with insulinomas were not in...