Endocrine Abstracts

Introduction: Although diagnostics and therapy are much improved over the years, women with gestational diabetes still have more adverse course and outcome of pregnancy than healthy women. Their pregnancies are more often complicated with the different forms of maternal and fetal morbidity. Our study investigates all cause early neonatal morbidity (neonatal jaundice, neonatal hypoglycemia, fetal distress syndrome and other) and newborns maturity and vitality in the groups of d...

Introduction: Diabetic retinopathy screening is the most accessible method of visualization of the affected small blood vessels in diabetic patients. Diabetic retinopathy is associated with age of patients, duration of diabetes, male sex, poor blood glucose control, central obesity, arterial hypertension, increased proteinuria, chronic inflammation and lipid disorders. Our study aims to compare type 2 diabetes patients with and without developed diabetic retinopathy regarding ...

Background: Trans-catheter arterial chemoembolization (TACE) is a method of treatment of unresectable liver metastases from neuroendocrine tumours (NETs) which is effective in the control of symptoms and tumour growth.Aim: To evaluate clinical outcome: radiologic, biologic, symptomatic response and safety of TACE procedure.Method: 31 patients underwent 140 TACE procedures during 2003–2011. Tumour responses were measured by CT ...

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy women. However, it is still unclear weather this is a consequence of PCOS per se or higher prevalence of obesity in this population. The aim of this study was to determine prevalence of MS in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We e...

Introduction: FRAX score is the ten-year estimated risk calculation tool for bone fracture which includes clinical data and hip bone mineral density measured by x-ray densitometry (DXA). The aim of the study was to elucidate the ability of the FRAX score in discriminating between bone fracture positive and negative postmenopausal women with subclinical hyperthyroidism.Material and methods: FRAX score calculation were performed in 27 postmenopausal women ...

Most of adrenal incidentalomas (AI) are nonfunctional, although some of those demonstrate an autonomous subtle cortisol hypersecretion that could lead to increased risk for osteoporosis. Several polymorphisms of glucocorticoid receptor (GR) gene have been found to alter glucocorticoid tissue sensitivity. The aim of this study was toinvestigate whether subclinical hypercortisolism (SH) and BclI variant of the GR gene have an impact on bone mineral density (BMD) in wome...

Introduction: Polycystic ovary syndrome is the most frequent ovarian dysfunction during the reproductive period. Its presence significantly impacts on the final scores of various Quality-of-Life (QoL) questionnaires. This pilot study aims to analyze the impact of hirsutism (H), as the component of PCOS, on the scores of determined generic (General Health Questionnaire-12, GHQ12) and disease-specific questionnaires (Polycystic Ovary Syndrome Questionnaire, PCOSQ) in PCOS subjec...

Introduction: Epidemiological studies show that one half of vertebral fractures, which play an important role in estimation of future fracture risk, remain unrecognized.Aim: To establish vertebral fracture frequency in relation to bone mineral density in postmenopausal women.Methods: Study comprised 146 postmenopausal women. On the grounds of spine and hip DXA T-score based on WHO criteria subjects were divided to healthy,...

A 36-years-old male with mild hypertension was diagnosed with pseudocystic tumor (67 mm) in pancreatic region and liver metastasis in April 2010. One month later, the extirpation of retroperitoneal mass and metastasis was performed in local medical centre. Pathohistological diagnosis was metastatic paraganglioma (Ki67, 3.5%). In June 2010, he was transferred to our Institution, and (131) I-metaiodobenzylguanidine (MIBG) scintigraphy was negative. However ((18) F) fluorodeoxygl...

Introduction: Most patients with neuroendocrine tumors (NETs) present with liver involvement at the time of diagnosis. Trans-catheter arterial chemoembolization (TACE) is accepted treatment of patients with non-resectable hepatic metastases from NETs.Aim: To analyze objective tumor response and clinical outcome in patients with hepatic metastases from NETs who underwent TACE.Methods: Thirty-one patients underwent 140 TACE procedure...