Endocrine Abstracts

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

Introduction: Congentital adrenal hyperplasia (CAH) comes to adult endocrinologist wheather as transition from pediatritian (Case 3) or as still without diagnosis (Case 1, 2, 4). The aim of this work is to describe typical forms of CAH initially sucessfuly treated with dexamethasone therapy.Case descriptions: Case 1: female, 1972y., presented in 1995y. (23y.) as severe hirsutism and infertility managed by team of gynecologists. She refus...

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover mar...

Introduction: The effects of TSH and thyroid hormones on bone turnover are well-known. The aim of this study is to examine the influence of osteoporosis (Op) and cardiometabolic syndrome risk factors on bone mineral density (BMD) in the population of age-matched, normotensive and nondiabetic females.Material and methods: Cross-sectional study involved 76 females (average age 53±10 years), divided into three groups: hypo-, hyper-, and euthyroid. Pres...

Introduction: It is common that patients with diabetes have a dominant parasympathetic dysfunction.Aim: Assessing the function of the autonomic nervous system in diabetic subjects.Methodology: Task force monitor was used for testing at rest and passive orthostasis evaluating baroreceptor sensitivity (BRS), spectrum variability of RR-interval of high frequencies HF RRI which is linked to the parasympathetic, low frequency variabilit...

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...

Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women...

Introduction: PCOS women appear to have an adverse body composition (BC). The aim of this study was to compare BC in lean PCOS in comparison to controls and to assess possible metabolic consequences.Methods: We evaluated 150 lean PCOS women (BMI: 20.96±2.06 kg/m2; age: 25.50±4.52 years) diagnosed using ESHRE/ASRM criteria, and 39 lean BMI-matched healthy women (BMI: 20.33±2.16 kg/m2; age: 27.67±5.39 years). BC wa...

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...