Endocrine Abstracts

Introduction: Although recognized as a risk factor in most staging systems, including the UICC TNM classification, the significance of microscopic extrathyroid extension (ETE) in papillary thyroid carcinoma (PTC) remains controversial. Despite this fact, its diagnosis by a pathologist following surgery for tumours ≤ 4 cm without metastases means an upstaging to pT3 and stage III in patients over 45 years, implying a poorer survival. Our study aimed to evaluate the impact...

Introduction: Familial partial lipodystrophy (FPL) is an autosomal dominant disease characterized by selective loss of subcutaneous fat from the extremities and gluteal region, with lipohypertrophy of the face, neck and trunk. It is usually tightly linked with severe metabolic complications. FPL type 3 results from peroxisome proliferator-activated receptor gamma (PPARG) mutations.Case presentations: Fifty three-year-old woman, referred to endocrinology ...

Introduction: Evidence implicates oxidative stress as mediator of diabetic complications. Furthermore, glucose variability (GV) is associated with oxidative stress and inflammation; however, association between GV and diabetes complications remains to be established. Our aim was to assess GV in patients with and without microvascular complications (MVC).Methods: We analysed 2454 and 6593 h of continuous glucose monitoring of patients with type 1 diabetes...

Introduction: Radioiodine (131I, RAI) is a safe and effective option for the treatment of Graves’ disease (GD). However, approximately 20% of RAI treated patients will have persistent disease or will relapse after the first treatment. Our aim was to identify the factors influencing the outcomes in RAI treatment for GD.Methods: We analysed 143 DG patients (116 women) treated with RAI between October 2002 and April 2014 and ≥12 months...

Introduction: Despite being a psychiatric disorder, anorexia nervosa (AN) is associated to severe systemic complications. The endocrine complications of AN are an opportunity for the diagnosis and treatment of this condition. The authors report the experience of the Endocrinology Department in the treatment of AN in inpatient setting.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology de...

Introduction: Hypophostemic rickets is characterized by phosphate renal loss associated with a primary defect of osteoblasts and metabolism of vitamin D. Marked bone turnover caused by high levels of parathyroid hormone attribute to these patients an elevated risk for hungry bone syndrome after parathyroidectomy.Case report: A 34-years old woman with a past history of Lynch syndrome and hypophostemic rickets associated with hyperparathyroidism and brown ...

Introduction: Glutamic acid decarboxylase (GAD65) is expressed by pancreatic beta cells and also by GABA (gamma-aminobutyric acid)-secreting neurons. Cerebellar ataxia associated with anti-GAD65 antibodies (antiGAD Ab) is a rare neurological disorder that frequently coexists with other autoimmune conditions, namely Diabetes Mellitus (DM).Case reports: We describe two cases of ataxia associated with antiGAD Ab. The first case is a 69-year-old obe...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare syndrome with autosomal dominant inheritance. It mainly involves the parathyroid glands (90%), the pancreas (60%) and the pituitary (40%). More than 300 different MEN1 germline mutations were already described.Objective: To characterize families with MEN1 followed at the Department of Endocrinology of the University and Hospital Center of Coimbra, Portugal, from 1990 until 2015.<p cl...

Introduction: In most cases, adrenal incidentalomas are non-functioning adrenocortical adenomas, but may also represent conditions in which therapeutic intervention is essential, such as pheochromocytomas, even with low index of suspicion.Case reports: Case report 1. Fifty-three-year-old male with history of arterial hypertension (HT), type 2 diabetes Mellitus and myocardial infarction, with a right adrenal incidentaloma found in abdomi...

Introduction: Definitive diagnosis of lymphocytic hypophisitis (LH) lacks a pathological analysis. The detection of pituitary antibodies (PAB) with the current methods presents variable results and its clinical utility is therefore limited. Recently, new methods were released for the interpretation of indirect immunofluorescence (IIF), which can increase the specificity for detection of PAB.Methods: We evaluated four patients followed in endocrinology co...