Endocrine Abstracts

Introduction: Congenital adrenal hyperplasia (CAH) is a prevalent disturb in female to male gender identity disorder (GID). However, psychoendocrinology of GID is not yet fully understood.Case Report: A 22-year-old patient(46, XX), was sent from Psychiatry-Sexology to Endocrinology consultation for GID to start hormonal treatment. Self-awareness as a male began at 12-year-old. Menarche at the age of 13 years. At 14-year-old, it was noticed overgrowth of ...

Introduction: Hypoparathyroidism is characterized by hypocalcemia and low or inappropriately normal levels of PTH. The most common cause of hypoparathyroidism is iatrogenic due to anterior neck surgery. In recent years it was documented that vitamin D insufficiency is widespread.Aim: To investigate the cause of hypocalcemia in thyroidectomized patients with PTH within the reference range.Methods: Retrospective review of clinical re...

Introduction: The patients’ nonadherence to treatment is a universal problem and has several related factors. Knowing these factors can provide information for planning of health actions. The aim of this study was to relate the prevalence of nonadherence to treatment for diabetes with sex, age, years of education, duration of diabetes and metabolic control.Description of methods/design: This is cross-sectional study. The data were derived from the d...

Hypophagia and increased energy expenditure under inflammatory condition, such as observed after bacterial lipopolysaccharide (LPS) administration, are associated with activation of JAK2–STAT3 signaling in the CNS. High fat diet (HFD) is known to induce hypothalamic resistance to leptin signaling mediated by JAK2–STAT3 pathway. In this study we investigated the expression of p-STAT3 in the hypothalamus and brainstem of HFD treated animals under LPS (100 μg/kg) s...

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...

Introduction: Primary aldosteronism (PA) is currently believed to be the most frequent form of secondary endocrine hypertension, accounting for 5–10% of all hypertensive patients. After confirming the diagnosis, adrenal venous sampling (AVS) is considered the most accurate means of distinguishing between unilateral and bilateral adrenal disease.Case report: Female patient, 36 years-old, referred to an Endocrinology appointment in May 2009 due to lef...

Introduction: miR143 and 145 seem to be involved in the pathogenesis of cortitotrophinomas by modulating the expression of MAPK7 and CCNL1 genes, which protein products are involved in cell proliferation, differentiation, and cell cycle progression. Objective: To analyze the modulation of miR-143 and -145 in the expression of MAPK7 and CCNL1 genes in corticotrophinomas and corticotrophic tumoral lineage (AtT20).Material and Methods: The expression of MAP...

Besides its critical functions as a reproductive hormone, 17β-estradiol (E2), plays an important role in the control of energy homeostasis. In experimental animals, reduction of circulating estrogen levels by bilateral ovariectomy leads to the development of obesity, which can be reversed or prevented by E2 treatment. E2 effects on energy balance resemble many similarities to the actions of leptin, key molecule involved in the control of e...

Repeated exposure to lipopolysaccharide (LPS) leads to endotoxin tolerance. Desensitization of hypophagia in response to repeated exposure to endotoxin is related to an inability of leptin to phosphorylate STAT-3 protein. Protein tyrosine phosphatase 1B (PTP1B) activity is known to contribute to leptin resistance by inhibiting leptin signaling. In this study, we induced endotoxin tolerance, injecting repeated LPS doses (6LPS) (100 μg/kg, i.p.) in comparison with single (1...

Introduction: Multinodular Goiter (MNG) is a thyroid neoplastic disease thirteen times more common in women than in men. While a local effect of estrogens at cellular levels could affect there can be other causes to explain the gender difference in incidence such as diet, environmental factors, genetic causes or alterations in metabolic pathways.Cellular effects of estrogens in human thyrocytes although previously studied are not completely clarified. So...