Endocrine Abstracts

Objective: There are contradictory results regarding the possible association of the TSHR polymorphism D727E with TMNG. Furthermore the influence of smoking on the thyroid volume has been reported by several authors. A possible association of smoking with thyroid nodules and particularly TMNG has not been investigated up to date.Methods: In this study, 88 patients with TMNG were included. Diagnosis was verified by ultrasonography, scinthiscan, and measur...

Background: Osteopetrosis is a rare chronic bone disease with high bone mineral densitiy due to impaired osteoclast activity or development. Genetic mutations result in severe infantile (autosomal recessive, incidence 1:200,000) and less severe adult forms (autosomal-dominant osteopetrosis/ADO). The incidence is estimated at 1:20,000 for noninfantile forms. In adults osteopetrosis is often asymptomatic with increased risk for bone fracture. Treatment is symptom-based (e.g. cal...

Introduction: To reliably assess glomerular filtration is of vital importance if oral antidiabetics are used. We compared the CKD-EPI model, a clinically established calculation model to assess creatinine clearance (CreaClear) with specimens from 24-h urine.Method: Inpatients (university hospital) with diabetes mellitus received a 24-h urine collection (24hClear) or since 2013 calculated CreaClear using CKD-EPI-formula (EPI). From 2014 to 2015 values of ...

Background: Women with polycystic ovary syndrome (PCOS) have lower health related quality of life (HRQL) and more symptoms of anxiety and depression than women without PCOS, where a higher BMI is positively correlated to both lower HRQL and more symptoms of anxiety and depression. Studies on women with PCOS and severe obesity regarding symptoms of anxiety and depression are lacking.Aims: To examine if women with severe obesity and PCOS have lower HRQL an...

Objectives: Endogenous Cushing’s Syndrome (CS) is a rare, chronic condition that results in high morbidity, caused by prolonged exposure to elevated levels of circulating free cortisol levels. Osilodrostat, a newly approved steroidogenesis inhibitor, has been shown to achieve fast and high rates of cortisol normalization, improving manifestations of hypercortisolism in patients with Cushing’s Disease (CD), a form of CS. We evaluated relative complete response (CR) ou...

Background: Bilateral adrenalectomy (BLA) is a treatment option for patients suffering from endogenous Cushing syndrome (CS). It consists of the surgical removal of both adrenal glands. Even though BLA offers immediate control of cortisol excess, given the risk of adrenal insufficiency, it requires life-long glucocorticoid and mineral corticoid replacement. It may lead to perioperative and long-term complications which affect patients’ quality of life (QoL). Health state ...

Purpose: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of SPECT/CT after radioiodine treatment of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis.Methods: One hundred and eighty-one consecutive patients with DTC were investigated after their first radioiodine treatment. The risk for recurrence based on ATA 2009 cl...

Objectives: TSH-producing pituitary adenomas account for 1–2% of all pituitary tumors and there is debate wether transsphenoidal surgery or medical treatment should be recommended as first-line treatment. This study summarizes the authors surgical experience and puts it into context of literature concerning non-surgical treatment of TSHomas.Methods: A retrospective analysis of 12 patients including imaging, laboratory testing, short-term and long-te...

Heterogeneity of diabetes mellitus (DM) determines difficulties in the diabetes type verification and further treatment. With this regard, in 2019 WHO published a new classification of DM with categories: “hybrid types of diabetes” and “unclassified diabetes” intended for use in clinical practice.Aim: To investigate the heterogeneity and clinical features of DM in young adult patients with an unspecified type of diabetes.<p cl...

Background: Ectopic Cushing Syndrom (ECS) represents approximately 12% of all patients with Cushing´s disease. Either ACTH (5–10%), CRH or cortisol is produced uncontrolled from nonpituitary tissue. Half of ECS cases are neuroendocrine lung tumors [carcinoid tumors > small cell lung carcinoma (SCLC)], but ECS is clinically apparent only in 1–5% of SCLC cases. Clinical features vary according to extent and duration of exposure to ACTH/Cortisol excess and in...