Endocrine Abstracts

Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male popu...

Apart from the crucial effects of vitamin D on bone health, vitamin D deficiency has been associated with various chronic conditions such as metabolic or reproductive disturbances. The polycystic ovary syndrome (PCOS) represents the most common endocrine disorder among women of reproductive age. Women affected by PCOS frequently suffer from oligo- or anovulation as well as from obesity and insulin resistance. There is accumulating evidence showing an association of vitamin D s...

Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome clinically presenting with recurring fractures, muscular weakness and pain. Laboratory values of affected patients are characterized by renal phosphate wasting and hypophosphatemia caused by an overexpression of fibroblast growth factor 23 (FGF- 23), a hormone belonging to the group of phosphatonins regulating phosphate and vitamin D homeostasis. Pathologically, it is secreted especially by small (and ...

Introduction: Familial Partial Lipodystrophies (FPLD) are rare genetic disorders characterized by marked loss of subcutaneous fat from the extremities with variable fat loss from the face and trunk. Patients with FPLD develop metabolic abnormalities including hypertriglyceridemia, insulin resistance, and diabetes mellitus, which are difficult to manage with conventional therapies including fibrates, statins and insulin. The BROADEN study evaluated the efficacy a...

Introduction: Familial Partial Lipodystrophy (FPLD) is a rare genetic disorder characterized by marked loss of subcutaneous adipose tissue from the extremities and is associated with a variety of metabolic abnormalities. While phenotypic elements of the disorder can vary across genotypes, symptomatic presentation, disease severity, and onset can also vary among individuals with the same disease-causing variant, or even among family members. Due to this variabili...

Background: It is still uncertain if subclinical thyroid disease or ‘high-normal’ thyroid function are risk-factors for atrial fibrillation (AF).Objectives: To examine the risk of AF in relation to thyroid function.Methods: Patients consulting their general practitioner from 2000–2009 in Copenhagen, Denmark, who underwent thyroid blood tests, were identified by individual-level linkage of nationwide registries. Patie...

Riedel thyroiditis is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. The etiological mechanism underlying RT are unclear. The prevailing view is that it is part of a generalized fibro-inflammatory process also involving other organs. Therapeutic options are not standardized (surgery, corticosteroids, and more recently tamoxifene). The aim of this work is to present three new cases, and the favourable evolution observed in one ...

Objective: Insulin-like growth factor 1 (IGF1) has a crucial role in growth and metabolism. A specifically designed autoantibody (aAb) assay against the IGF1 receptor (IGF1R-aAb) is able to detect IGF1R-aAb in serum. As the IGF1R has shown involvement in many functional pathologies (e.g. in the Laron syndrome), we aimed to investigate the role of IGF1R-aAb in a large population-based cohort of middle-aged volunteers and their potential effects on anthropometric, osteological a...

BackgroundRoutine biochemical assessment in patients with congenital adrenal hyperplasia (CAH) includes measurement of serum 17–hydroxyprogesterone (17OHP), androstenedione (A4) and testosterone (T) and their metabolites in urine. Several studies have also described 11–oxygenated 19–carbon (110 × C19) steroids as a clinically relevant androgenetic source and highlighted their potential as markers for evaluation of adrenal androgen exc...

Background: Hashimoto’s thyroiditis (HT), the most prevalent autoimmune disorder of the thyroid (AITD) is characterized by the presence of circulating autoantibodies, induced by a not fully understood dysregulation of the immune system. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present investigation was to evaluate whether a panel of nine selected miRNAs differs in ser...