Endocrine Abstracts

Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every ...

The aim of this study was to analyze retrospectively (2003–2007) the coexistence of NTD with TAD (Graves’ and Hashimoto’s diseases) in an iodine-replete area.The first study group included 381 cases with Graves’ hyperthyroidism, not previously treated with surgery or radioiodine therapy. The second group comprised 213 patients with hyperplasic Hashimoto’s disease and heterogeneous functionality.NTD was diag...

cAMP signaling systems play a critical role in regulation of thyroid cell proliferation and function. Besides the well known protein kinase A (PKA) cascade, Epac (exchange protein directly activated by cAMP) depicts a novel effector of cAMP. Epac is directly activated by cAMP and in turn stimulates kinase cascades like Akt kinase, phospholipase Cε and MAP kinases as well as the Ras-like GTPases Rap1 and Rap2. As data about the impact of Epac on cAMP signaling of thyroid c...

Sarcopenia is a degenerative loss of skeletal muscle mass, quality, and strength. It increases the risk of falls and fractures, is associated with cardiac and respiratory disease and cognitive impairment and leads to mobility disorders. It decreases quality of life, leads to loss of independence, placement in long-term care and finally death. A variety of indices and parameters can be used to define sarcopenia. According to literature, matrix-GLA-protein (MGP) is associated wi...

Background: Patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) require lifelong glucocorticoid replacement therapy, including stress dose adjustment to prevent life-threatening adrenal crises (AC). Previous studies indicate a high incidence of inadequate stress dose adjustment and AC in patients with CAH. The aim of this study was to prospectively assess AC incidence, frequency and details of stress dose adjustment as well as knowledge of the d...

Repeated blood sampling is required in certain clinical and research settings, which is currently performed by drawing blood from venous catheters requiring manual handling of each sample at time of collection. A novel body-worn device for repeated serial samples, Fluispotter®, with automated extraction, collection and storage of up to 20 venous dried blood spot samples (DBS) over the course of 20 h may overcome problems with current methods for serial sampling. The purpo...

The proline rich and Gla domain genes PRRG1-4 encode for short transmembrane proteins. PRRG proteins contain a Gla domain with glutamic acid residues which are gamma-carboxylated in a vitamin-K-depend manner. In a previous study, we were able to show a decrease in PRRG1 gene expression during intima thickening in atherosclerosis. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the vitamin-K-dependent protein PRRG1 with cardiovascular...

Background and aim: Insulin resistance is associated with type 2 diabetes and obesity but recent studies suggest that it may also be associated with type 1 diabetes (T1D), which may affect glycemic control. Hypoglycemia is a dreaded condition among patients with T1D and may also limit optimal glycemic management. We aimed to investigate insulin sensitivity and metabolic adaptions in healthy control subjects and T1D subjects.Material and methods: <!--SUB:...

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...

Matrix–GLA–protein ( MGP), independent of its posttranslational modification(s), has been associated with bone parameters and cardiovascular risk in patients with and without type 2 diabetes mellitus (T2DM). We investigated whether uncarboxylated, dephosphorylated MGP (uc–dp MGP), total MGP or both are associated with anthropometric and cardiovascular parameters such as carotid to femoral pulse wave velocity (PWV), intima–media thickness (IMT) and relat...