Endocrine Abstracts

Introduction: • Vitamin D deficiency is thought to impair insulin action and glucose metabolism.• Migrants who live in Western countries seem to have lower 25(OH)VitD levels, not only from their white counterparts but also from their native populations in their country of origin.Objectives: • We investigated a cohort of predominantly white Greek Caucasian and Bangladeshi immigrant patients with diabetes mellitus in o...

Objective: Thyroid autoimmunity has been proposed as a risk factor for impaired health-related Quality of Life (HRQoL), depression and anxiety, though evidence is still limited. The aim of the current study is to assess the association of thyroid autoimmunity with quality of life in patients with benign thyroid disease.Design: A cross-sectional study was implemented, that included consecutive patients with benign thyroid diseases who visited the outpatie...

Case historyA 23-year-old woman with no significant past medical history and normal renal function was incidentally found to be hypercalcaemic in 2003. Following investigation, she was diagnosed with primary hyperparathyroidism. She underwent three-gland parathyroidectomy; histology demonstrated hyperplasia. Her bone function remained normal, but 4 years later she was found to have normocalcaemic hyperparathyroidism. Sestamibi demonstrated uptake inferio...

Background: Little is known about the long-term outcome of the thyroid function in Graves’ disease in a large epidemiological setting.Objective: The aim was to evaluate the long-term outcome of the thyroid function in patients diagnosed with Graves’ disease in Denmark in the period 1995-2018. Our research objectives were to investigate the incidence of disease, use of antithyroid drugs, radioactive iodine, thyroidectomy and levothyroxine during...

The G protein-coupled receptor (GPCR), follicle stimulating hormone receptor (FSHR) plays a critical role in ovarian function and reproduction, with multiple functions in follicle growth, maturation, survival, and steroid hormone production. Yet how FSH/FSHR mediates these pleiotrophic physiological roles remains unknown. Numerous studies indicate GPCRs can regulate and diversify their actions through receptor-receptor association and the formation of dimers/oligomers. Moreove...

Background: Adrenal incidentalomas (AI), the finding of asymptomatic adrenal lesion on unrelated imaging, represent an increasing number of endocrine referrals. In 2022, we introduced a nurse-led pathway to manage AI.Aim: To assess the cost savings and patient experience of a telephone nurse-led AI service at Musgrove Park Hospital.Methods: Records for patients seen in the AI clini...

Introduction: Paediatric obesity is increasing globally. By 2050, obesity is expected to cost the UK NHS £10 billion annually.1 Physical activity and exercise are recognised interventions to reduce BMI.2 However, the physiological response to exercise is not understood. Understanding physiological responses in people with obesity (PwO) can inform the prescription of safe rehabilitation exercise programmes. This pilot study explored t...

Introduction/Background: Adrenal incidentaloma is defined as an asymptomatic adrenal mass greater than 1 cm, discovered during imaging performed for another purpose1. The main goal when discovering such a tumor is to rule out a hormonally active lesion or a malignant condition. Radiological characteristics on non-contrast CT or MRI can help to determine if a lesion is benign. If the lesion nature remains indeterminate after these exams, it is recomm...

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are an extremely heterogenous group of diseases with complicated treatment and management decisions. For example, patients with Multiple Endocrine Neoplasia Type 1 (MEN1)-associated gastrinomas present with more aggressive tumors and poorer outcomes. Recent work has shown that sequencing (transcriptomic, proteomic) can phenotype GEP-NETs to accurately reflect important clinical parameters such as tumor aggress...

Background: Metastatic paragangliomas (PGL) and pheochromocytomas (PCC) are rare neuroendocrine diseases with an incidence of 2 to 8 people per million, a prevalence between 1:2500 and 1:6500 and a strong hereditary disposition. However, due to the rarity of the disease, there is relatively limited data on treatment options, including radionuclide therapy using radioisotope analogs of MIBG and dotatate. There are a few published small series on clinical benefits of treating PG...