Endocrine Abstracts

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

Multiple Endocrine Neoplasia is characterised by the occurrence of tumours involving two or more endocrine glands within a single patient. MEN are autosomal dominant disorders. Four forms have been described: MEN 1 due to menin mutations, MEN2 (previously MEN2A) due to mutations of a tyrosine kinase receptor encoded by the rearranged during transfection (RET) protoncogene, MEN3 (previously MEN2B) due to RET mutations and MEN4 due to cyc...

Introduction: The adult Turner Syndrome (TS) clinic at UCLH has collected data on over 800 women, attending for up to 20 years comprising over 8000 clinic visits. Data from this cohort forms the Turner Life Course Project. This large dataset allows analysis of pathogenesis of common chronic conditions including diabetes mellitus (DM) and hypothyroidism. There is some debate about the classification of DM associated with TS, with an over representation of up to 11-fold of type ...

Aim: To explore the metabolic phenotype of Male Obesity-associated Secondary Hypogonadism (MOSH) and following treatment with long-acting intramuscular (IM) testosterone undecanoate.Methods: A prospective observational pilot study on metabolic effects of IM testosterone undecanoate in MOSH (Hypogonadal [HG] group, n=13), including baseline comparisons with controls (Eugonadal [EG] group, n=15). Half the subj...

Multiple Endocrine Neoplasia is characterised by the occurrence of tumours involving two or more endocrine glands within a single patient. MEN are autosomal dominant disorders. Four forms have been described: MEN 1 due to menin mutations, MEN2 (previously MEN2A) due to mutations of a tyrosine kinase receptor encoded by the rearranged during transfection (RET) protoncogene, MEN3 (previously MEN2B) due to RET mutations and MEN4 due to cyc...

A male, born in 1957, with history of familial spinocerebellar ataxia, Type 2 diabetes (diagnosed in 1999), asthma, learning difficulties, chronic pancreatitis, recurrent falls, multiple low trauma fractures and osteoporosis was referred to Endocrinology Department in 2019. He sustained a right radial fracture at the age of 34 (1992), followed by comminuted right distal radius and Ulna styloid process fracture in 2002, Left and right Neck of Femur fractures in 2013 and 2014 re...

Objectives: Thyroid peroxidase (TPO) is a key enzyme in the synthesis of thyroid hormones and is a target for autoimmune responses in autoimmune thyroid disease. TPO autoantibody (TPOAb) binding epitopes have been mapped on the peroxidase domain (POD) and the complement control protein like domain (CCP). This study aimed to solve the molecular structures of TPO bound to TPO antibodies.Methods: An extracellular domain (ECD) of human TPO (amino acids; aa 1...

Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...

Background: It is widely believed that increased circulatory concentrations of long-chain saturated fatty acids (LC-SFA) significantly contribute to the death and dysfunction of pancreatic β-cells in the development of type 2 diabetes (T2D). The mechanism by which LC-SFA cross the β-cell plasma membrane has not been fully established. This work aims to characterise the mechanism underpinning this uptake. Ultimately, regulation of LC-SFA entry may maintain β-cell...