Endocrine Abstracts

Background: Hypopituitarism is common in patients with pituitary tumors. Still, the influence of pituitary tumor surgery on gonadal function and reproductive health remains underexplored.Objective: a) To assess gonadal function and its impact on quality of life (QoL) in patients with non-functioning pituitary adenomas (NFPA) before and after transsphenoidal surgery (TSS), b) to identify factors that predict recovery of gonadal function following TSS, and...

A 23-year-old gentleman with a 9-month history of extreme tiredness, muscle aches and pains, weight gain, cold intolerance and constipation presented to hospital with severe lethargy and dizziness and vacant episodes of increasing frequency. Initial examination revealed him to have a pulse rate of around 66 beats per minute. He was haemodynamically stable. A resting ECG showed an elevated ST segment of more than 2 mm with descent to an upward convexity to an inverted T wave es...

Aims: To study changes in bone mineral density (BMD), bone mineral parameters, metabolic profile, body composition and quality of life at base line and 6 months following parathyroidectomy, in subjects with primary hyperparathyroidism (PHPT).Material and methods: This prospective study was conducted over 18 months with first 12 months of recruitment and next 6 months for follow-up. Sixty-eight patients with PHPT who underwent surgery were compared with 1...

Oxytocin is a hormone and neurotransmitter with antiinflammatory and neuroimmune-modulatory properties. Physiological states of elevated plasma oxytocin levels are associated with reduced hypothalamic–pituitaty–adrenal response to different stressors. We examined the effect of exogenous oxytocin administration on bacterial endotoxin induced innate immune responses in humans. Ten healthy men received in a randomized, placebo-controlled, cross-over design (1) placebo, ...

Aim: To determine the aetiology of Addison’s disease in patients admitted to a tertiary care hospital in South India from 2001 to 2007.Method: Forty-five patients with Addison’s disease were admitted during this period. Etiological work up was carried out in all these patients.Results: Thirteen patients (29%) had a possible infectious cause: 11.1% histoplasmosis, 8.8% confirmed tuberculosis, 4.4% presumed tuberculosis, 4...

3-Iodothyronamine (T1AM) is a novel endogenous derivative of thyroid hormone (TH), recently described by Scanlan et al. (Nat. Med. 10: 638, 2004). In vitro, T1AM can stimulate the production of cAMP via activation of a heterologously expressed G protein-coupled receptor (GPCR) now referred to as trace amine-associated receptor 1 (TAAR1; Lindemann et al. Genomics 85: 372, 2005). In adult, unanesthetized C57Bl6/J mice, T1AM produces prof...

Aim: To study patients with Bone metastases in papillary carcinoma thyroid and the role of I-131 ablation.Methods: Retrospective analysis of patients with papillary carcinoma of thyroid between 1960–2005 in our institution.Results: Of 1538 patients who had thyroid carcinoma, papillary carcinoma was seen in 1228 (79.8%), and 21 patients with papillary carcinoma (1.71%) had bone metastases. Seventy percent of them were between 4...

Aim of the studyA relative can be an asset in dealing with chronic illnesses such as acromegaly where quality of life is altered even after remission. However, it has been shown that quality of life of caregivers can also be impacted. Our main objective was to explore the consequences of acromegaly in remission in the patient-relative dyad in a matter of quality of life and self-esteem.MethodsIn this French m...

Background: Sporadic aldosterone-producing adenomas (APA) are relevant cause of endocrine related hypertension in Primary Aldosteronism (PA). Next generation sequencing techniques have identified somatic mutations in APA harbored in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CTNNB1 and PRKACA genes. Yet, a number of APA harbor no mutations in candidate genes (designated as wild type, WT) and little is known about genotype/phenotype correlation.Objectives: We invest...

Objectives: To study the clinical, biochemical, imaging profile and treatment outcomes of patients with malignant pheochromocytoma and paraganglioma(PPGL). Also, to compare their characteristics with non-malignant PPGL to identify the factors that may predict metastasis.Methods: This retropsective cohort study included 212 patients with PPGL managed at our centre over a period of 10 years(2013-2022). Their clinical, bioc...