Endocrine Abstracts

Introduction: Thyroid ultrasonography and fine needle aspiration (FNA) are the most useful techniques in the evaluation of thyroid nodules. They are cheap, fast, minimally invasive and high precision methods. The FNA can be performed by palpation or ultrasound guidance. The use of ultrasound reduces the nondiagnostic results rate. However, the cytologic diagnostic accuracy depends on the technique and pathologist experience. Ultrasonography confirms the presence of a thyroid n...

Introduction: Primary mitochondrial disease is a heterogeneous group of disorders of mitochondrial energy metabolism. Neuromuscular symptoms are the main features, but diabetes mellitus (DM) is present in many patients. DM is related to a deficient energy production, which leads to decreased insulin secretion and ultimately to β-cell apoptosis. In most cases, DM has an insidious onset with requirement of insulin 2-4 years after diagnosis. About 20% of cases present with a...

Introduction: Metastasis to the thyroid gland is a rare phenomenon and is associated with primary tumors of the kidney, lung, breast, colorectal, and sarcoma. Thyroid metastases account for only 0.4-3.0% of all malignant neoplasms of the thyroid and occur more frequently in patients with goiter, thyroiditis, or nodules than in patients without previous thyroid pathology.Case report: A 57-year-old woman with a history of clear cell renal cell carcinoma (C...

Introduction: The existence of clear differences between the biological course and clinical behaviour of minimally invasive (MI) and widely invasive (WI) follicular thyroid carcinomas (FTC) is still debatable. The present study was conducted to outline the clinical differences between MI and WI-FTC and evaluate outcomes in both tumors.Methods: We conducted a retrospective cohort study involving 80 cases of FTC. The comparison between MI-FTC and WI-FTC in...

Introduction:: Gender dysphoria (GD) is featured by significant difference between the individual’s expressed gender and the gender others would assign him or her, with marked distress in social and occupational functionality, according to DSM-V classification. We report the experience in the clinical evaluation and the results of hormonal therapy and sex reassignment surgery in a hospital center.Methods:: It was conducted a retrospective analysis o...

Introduction: Pheochromocytomas are adrenomedullary catecholamine-secreting tumors. These account for <0.1% of all causes of hypertension and may be related to potentially fatal hypertensive crises. Can appear as sporadic tumors or associated with familial syndromes.Malignancy occurs in 15–20% of the cases and is characterized by local invasion or distant metastasis rather than capsular invasion. Tumor recurrence has been reported with a frequen...

Background: Germline AIP mutations confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated pituitary adenomas (FIPA); AIP mutations account for 50% of familial acromegaly. AIP-related PA are GH, PRL-secreting or non-secreting. Little is known about AIP expression in PA. Although the prevalence is low, identifying AIP mutations in apparently sporadic PA is important for studying at-risk relatives. Pre-screening criteria would help select ...

Introduction: Pheochromocytoma (Pheo) and paragangliomas (PGL) are rare catecholamine-producing tumors.Near 35% of patients have disease-causing germline mutations.10% are malignant although the malignancy rate differs accordingly to the genetic background.Purpose: This study aims to characterize the sample of patients followed on a tertiary Portuguese Center and associate the presence of genetic mutation with clinical presentation.<p class="abstext"...

Introduction: Papillary thyroid carcinoma (PTC) is a differentiated thyroid carcinoma and is the most common variant. It is more frequent in women and the median age at diagnosis is 45 years. Most PTC are clinically indolent, have a good prognosis and low incidence of distant metastases. The more frequent locals of distant metastases are bone and lung. Brain metastases are very rare and associated with a poor prognosis.Case report: We present a case of a...

As part of the Transregional Collaborative Research Centre TR-SFB134 we study central insulin effects on hedonic food processing across the life-span. So far, 48 younger participants across a wide weight-range (BMI: 18–38) were investigated with functional magnetic resonance imaging (fMRI) during a hedonic food processing task after receiving intranasal insulin (160UI) or placebo in a cross-over design after an overnight fast. Imaging results during the placebo session re...