Endocrine Abstracts

Aside its growth promoting effects, growth hormone (GH) displays other actions upon carbohydrate, lipid and protein metabolisms, and possibly also direct central nervous system effects. Fourteen adult pituitary dwarves (mean height of 132.3±8 cm, mean age of 30.7±9.6 y), 5 women and 9 men, never having received rGH therapy, were investigated. Body composition (BC) was assessed by bioelectrical impedance, and bone mineral density (BMD) was evaluated by quantitative ul...

Polycystic ovary syndrome (PCOS) is a major source of psychological morbidity and can negatively affect quality of life. The aim of the study was to identify characteristics of self-concept in female patients diagnosed with PCOS (n=22, mean age 26+/− 11 years) and comparative analysis with a control group (n=22).Methods: Psychology questionnaire, selection tests based on geometrical figures/ words and also graph logical analysis were ...

Aim of the study: Assessing prevalence and severity of erectile dysfunction in patients with pituitary diseases.Materials and methods: International Index of Erectile Function (IIEF) and Sexual Health Inventory for Men (SHIM) questionnaires were used to assess erectile dysfunction (ED) in 83 patients having pituitary diseases (31 patients had hypopituitarism, 11 diabetes insipidus, 10 prolactinomas, 11 nonfunctional adenomas, 16 operated acromegaly, 4 GH...

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...

Topical application of corticosteroids is frequently used in the therapy of dermatological diseases due to their anti-inflammatory and immunosuppressive effects. On the other hand, when reaching pharmacological levels, exogenous corticoids frequently lead to complete Cushing syndrome, including skin modifications, irrespective of the route of administration. We describe four cases of iatrogenic Cushing’s syndrome triggered by topical application of corticoids. The first t...

Subacute thyroiditis (SAT) is a self-limited inflammatory disease of presumed viral etiology, characterized by pain and thriphasic functional thyroid evolution. We report the case of an 54-years-old woman hospitalized in 02.2008 at the Gastroenterology Department for fever, diahreea, significant weight loss (5 kg in one month), with the suspicion of Crohn’s disease (CD). Two weeks before she presented a subfebrile episode with bilateral jugular lymphadenopathy, dysphagia,...

Patient DE, a 49-year-old woman, was operated in 2005 for two giant-cell tumours of the mandible, and in 2008 for another tumour with the same localisation and histology. Inferior cervical ultrasound after the second surgery revealed a parathyroid adenoma of 20×27×15 mm behind the lower pole of the right thyroid lobe, confirmed by Tc tetrofosmin scintigraphy. The patient had metabolic features suggestive for primary hyperparathyroidism: calcium – 10.9 mg/dl (nor...

Leopard syndrome (LS) is a rare autosomal dominant disease of variable penetrance and clinical expression. LEOPARD is an acronym for the major features of the disorder: lentigines, ECG conduction abnormalities, Ocular hypertelorism, pulmonary stenosis, abnormal genitalia, retardation of growth, and deafness. LS is caused by different mutations in PTPN11 gene (protein-tyrosine phosphatase, nonreceptor-type, 11), allelic with Noonan syndrome (NS). The diagnosis is established if...

Papillary thyroid carcinoma is a slow growing tumor and is reputed to have an excellent prognosis. In 10–20% of cases, the presence of lymph node metastases led to diagnosis.Objective: To present a patient with enlarged lateral cervical masses, present for 10 years, that proved to be lymph nodes with metastatic thyroid papillary carcinoma.Case report: We report a case of an 26-year-old female patient with 10 years evolution of...

Infundibulohypophysitis is an unusual inflammatory condition that affects the infundibulum, the pituitary stalk and the neurohypophisis and may be a part of a range that includes lymphocityc hypophysitis. It occurs mainly in women and most often presents in later stages of pregnancy. Infundibilohypophysitis usually presents with diabetes insipidus. The case of a 30-year-old woman with diabetus insipidus diagnosticated in the third trimester of the pregnancy is reported. She wa...