Endocrine Abstracts

A 73 year old male presented to his optician with reduced vision in his right eye. He was found to have a right sided visual field defect and referred to Opthalmology. An MRI scan was arranged which showed a 29 x 22 x 17mm pituitary fossa mass, elevating and flattening the optic chiasm. He was therefore referred urgently to Endocrinology. He denied any symptoms other than some lethargy, a mild headache and erectile dysfunction. His anterior pituitary function tests are display...

The increase in thyroid disease frequency has been observed recently. It may be attributed to the changing iodine status, endocrine disruptors, as well as better availability of ultrasound and laboratory tests. The aim of the study was to assess the occurrence of newly recognized thyroid diseases during long-term follow-up.Material and methods: Study was carried out in 2010–2012 in Krakow area. It included 266 patients aged 23–81 years (168 fem...

Introduction: The association between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) has been investigated for several years from different perspectives. In spite of that, there were only few attempts to design a common frame of references to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. The aim of this study is to investigate the clinical characteris...

Germinal mutations in protooncogene RET are associated with the inherited medullary thyroid carcinoma (MTC) which occurs as the sole manifestation of disease (FMTC) or, more frequently, as the part of multiple endocrine neoplasia (MEN2). The contribution of RET polymorphism to the occurrence of apparent sporadic MTCs is controversial. In our previous study we have found out that the frequency of RET 769 CTT>CTG polymorphism in patients with MTCs is not significantly higher...

Endocrinology, Diabetology, Nutrition and Metabolic Diseases DepartmentIbn Rochd University Hospital of Casablanca, MoroccoNeurosciences and Mental Health Laboratory Faculty of Medicine and Pharmacy-University Hassan II- Casablanca-MoroccoIntroduction: Insular carcinoma of the thyroid is an extremely rare tumor, accounting for 4% of cases, with a poor prognosis and malignancy intermediate between differentiat...

Introduction: DSD is a group of disorders by which there is discrepancy between genomic sex and phenotypical sex. Most of cases of DSD are picked up during neonatal period due to ambiguous genitalia. Few cases are diagnosed in adolescence or even at puberty due to various causes like mild ambiguity, complete phenotype sex reversal, lack of breast development and primary amenorrhea, we review a case of 46XX CAH girl due to CYP21 hydroxylase deficiency which was diagnosed late a...

Background: X and Y chromosomes carry many genes that direct development and gametogenesis. Rearrangements associated with X chromosome may have a role in abnormal phenotypes. We presented a case of primary amenorrhea with normal karyotype but centromere thickness in 13th chromosome (13 cenh+), this is the first case in literature.Case: A 18-year-old woman admitted to endocrinology clinic with complaints of primary amenorrhea and a failure in ...

Objective: The role of sex in pulmonary hypertension (PAH) is not fully known. The majority of animal studies have suggested a protective role of female sex hormone in PAH. But women of various ages are more subjected to PAH compared with male. The aim of current research was to test the hypothesis that the level of oxygen in the inspired air can influence on the effect of estradiol on the development of experimental PAH in female rats.Methods and design...

Background: Vitamin D deficiency is very common in older persons. It is not clear how serum 25-hydroxyvitamin D (25(OH)D) levels change during aging.Objective: To examine longitudinal changes in serum 25(OH)D levels in two representative cohorts of Dutch older persons during 6 and 13 years of follow-up, respectively.Methods: Data of the Longitudinal Aging Study Amsterdam (LASA) were used, an ongoing cohort study in older persons. T...

Introduction: Thyroid cancer is the most common endocrine cancer and medullary thyroid carcinoma (MTC) is one of the most malignant thyroid tumours which occur in both hereditary (25%) and sporadic (75%) forms. Mutations of the RET proto-oncogene in MTC development have been well demonstrated. The aim of the study was to investigate the mutational spectrum of exons 3, 5, 8, and 10–18 of RET proto-oncogene in MTC patients.Material and methods: This r...