Endocrine Abstracts

Background and Aims: Awareness and knowledge about any disease is the first step to prevent and treat it. Osteoporosis is a worldwide health problem. Osteoporosis is characterized by decreased normal bone density. More than 8.9 million fractures worldwide annually are caused by osteoporosis; these fractures are a significant cause of morbidity and mortality. Evidence suggests that the modification of several lifestyle habits, diagnostics, prevention and treatment could assist ...

Purpose: To investigate the carbohydrate metabolism in depend on acromegaly treatment.Material and methods: 23 patients with newly diagnosed acromegaly (NA) were observed. Carbohydrate metabolism were investigated after somatostatine analogues treatment (SSA) (14 patients) or after surgery (TSA) (9 patients). Groups were comparable on age, BMI, acromegaly duration. Were researched HbA1c, fasting plasma glucose level (FPG), indexes of insulin resistance (...

BackgroundThe usage of Immune checkpoint inhibitors such as pembrolizumab grows over time due to their positive effect on survival and quality of life in patients with advanced cancer. The frequency of immune-related adverse events (IRAEs) associated with this drugs grows over time accordingly. Several endocrine-IRAEs of pembrolizumab are described in the literature and the thyroid disfunction is the most common.Case description</p...

Introduction: The aim of study was to analyse the effect of long-chain polyunsaturated higher ω-3 fatty acids (PUFAs) on the arterial stiffness parameters in patients with type 2 diabetes (T2DM) and cardiovascular autonomic neuropathy (CAN).Description of methods: The study involved 39 patients with moderate CAN (55.2±3.8 years, HbA1c 7.1±0.5%. The aorta (AIxao), brachial augmentation index (AIxbr), pulse wave velocity (PWV) were assessed ...

Patients with Familial Hypercholesterolaemia (FH) have premature Cardiovascular disease and have a standardised mortality ratio nine times greater than normal. FH must therefore be correctly diagnosed and treated aggressively. Referral for FH is based on fulfilling the Simon Broome’s (SB) Criteria. We aimed to evaluate practice at Queen Alexandra Hospital with regards to referral for FH genetic mutation. We set out to see whether SB’s criteria were being fulfilled wh...

We carried out retrospective clinic-statistical analysis of patients’ case reports been undergone for surgery. 1965–741975–841985–941995–2005Number of operations1055200436323551</t...

Graves’ disease (GD) has been recognised for more than 100 years, its pathophysiological mechanisms are incompletely understood.Aim: To investigate the helper- (Th-cells) and regulatory T-cells (Treg) influence on B-lymphocytes phenotypic composition of blood and thyroid tissue in GD.Materials and methods: The study included 43 women with GD, mean age 39.95±14.38, who were performed the epifascial thyroidectomy and 67 hea...

Thyrotoxicosis has been linked to osteoporosis and increased fracture risk. On the other hand, decreasing serum levels of estrogens in postmenopausal women potentially may increase effect of thyroid hormones on bone tissue. Dual-energy X-ray absorptiometry is an accurate and precise method of determining BMD, and has been wildly-used for diagnosing osteopenia and osteoporosis. The aim of our study was to study by means of DXA the peculiarities of bone loss in women of differen...

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 1–4 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 1–4 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...