Endocrine Abstracts

Introduction: Irisin is a recently reported adipo-myokine. To date, many researchers underline its significant influence on the body metabolism and thermogenesis. Secreted by muscle and adipose tissue irisin promotes a program of subcutaneous white adipose tissue ‘browning’. As a result, heat production and general energy expenditure raise. Irisin is considered to be a potential mediator of the health-promoting role of physical exercises. Its possible compensatory ro...

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

Introduction: Severe thyroid disorders are usually associated with myopathy. Muscle weakness may occur in both hypothyroidism and hyperthyroidism. However, only hypothyroid patients experience increase in creatine kinase levels, depicting destruction of muscle fibers. There were recently some reports showing the lowering in serum concentrations of large sarcomere proteins – titin (TTN) and dystrophin (DMD) in patients with hypo- and hyperthyroidism....

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

Severe thyroid disorder are associated with important metabolic changes. After restoration of euthyroidism, as a result of proper treatment, usually body metabolism also normalizes. Up to date, there are conflicting reports about the changes in body composition of patients during treatment of severe hyperthyroidism and hypothyroidism. The aim of this study was to evaluate the body composition and glucose level changes in subjects affected by Graves disease and autoimmune thyro...

Irisin is a recently reported, widely discussed new adipo-myokin secreted mainly by muscle tissue. It is a cleaved and secreted part of fibronectin type III domain containing 5, encoded by the FNDC5 gene. Some of the previously published studies claim that alterations of irisin levels in patients affected by thyroid diseases may be connected mainly with accompanying myopathy. However, to date it has not been evaluated, whether the changes in expression of FNDC5</e...

Introduction: Many original research studies describes significant impact of thyroid hormones on muscle tissue. Hypo- and hyperthyroidism cause both functional and structural damage of muscles presented by many signs and symptoms of thyroid myopathy. Thus, it is interesting to compare the impact of thyroid dysfunction on hormones secreted by muscles – myokines.Aim: The main goal of the project is to assess serum concentration of three myokines &#150...

Introduction: The adipose tissue secrets visfatin, that might have metabolic effect. Changes of visfatin serum concentrations have been observed in different thyroid pathologies. Thyroid hormones affect metabolism, thus, both hypo- and hyperthyroidism might significantly alter body composition.Aims of the study: We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with ins...

Purpose: The aim of the study was to investigate changes of visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients.Material and methods: The study was designed as a single-center, cross-sectional with consecutive enrollment. We included all patients with newly diagnosed overt hyperthyroidism (Graves’ disease or toxic nodular goiter). Each subject underwent physical examination, laboratory investigation, body composi...

Background: Amyloidosis is defined as the accumulation of amorphous, proteinaceous material in different parts of the body. It can be primary or secondary, having decreased the incidence of this last one due to the current therapeutic landscape of infectious and autoimmune diseases. This material can be deposited in the thyroid gland resulting in an enlargement known as Amyloid goiter. Although amyloid infiltration in thyroid is common, the occurrence of clinically enlarged th...